• Vaccine Name: Rabies virus DNA vaccine encoding the ERA glycoprotein
• Target Pathogen: Rabies virus
• Target Disease: Rabies
• Vaccine Ontology ID: VO_0004372
• Type: DNA vaccine
• Status: Research
• glycoprotein gene engineering:
  • Type: DNA vaccine construction
  • Description: This DNA vaccine expressed the full-length cDNA of the ERA rabies virus glycoprotein (Lodmell et al., 2000).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000026
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Neutralizing antibody titers were enhanced following primary i.m. vaccination with DNA and MPL® (Lodmell et al., 2000).
• Efficacy: After virus challenge, in the group of mice that were vaccinated with MPL, 4 of 6 mice with individual neutralizing antibody titers of 1:10 survived viral challenge. In addition, in the group of mice that did not receive MPL, 100% of the mice survived viral challenge after their second booster (Lodmell et al., 2000).