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Vaccine Detail
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M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83 |
| Vaccine Information |
- Vaccine Name: M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83
- Target Pathogen: Mycobacterium tuberculosis
- Target Disease: Tuberculosis
- Vaccine Ontology ID: VO_0004362
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Ag85B from M. tuberculosis H37Rv
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pJW4303 expressed Ag85B of H37Rv (Cai et al., 2005).
- Detailed Gene Information: Click Here.
- MPT64
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pJW4303 expressed MPT64 of H37Rv (Cai et al., 2005)
- Detailed Gene Information: Click Here.
- MPT83
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pJW4303 expressed MPT83 of H37Rv (Cai et al., 2005).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000276
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Combined DNA vaccines including Ag85B, MPT64, and MPT83 formulated in IL-2 provided an efficient method for generating strong and sustained protective immunity in the spleen and lungs of experimental mice following i.v. challenge with M. tuberculosis H37Rv (Cai et al., 2005).
- Information about this animal model: Mouse Model for TB research
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| References |
Cai et al., 2005: Cai H, Yu DH, Tian X, Zhu YX. Coadministration of interleukin 2 plasmid DNA with combined DNA vaccines significantly enhances the protective efficacy against Mycobacterium tuberculosis. DNA and cell biology. 2005; 24(10); 605-613. [PubMed: 16225391].
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