• Vaccine Name: HIV DNA vaccine VlJns-tPA-gp120
• Target Pathogen: Human Immunodeficiency Virus
• Target Disease: Acquired Immunodeficiency Syndrome (AIDS)
• Vaccine Ontology ID: VO_0004351
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Rhesus monkey
• gp120 gene engineering:
  • Type: DNA vaccine construction
  • Description: This vaccine encoded gp120 from HIV IIIB (Lekutis et al., 1997).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005044
• Immunization Route: Intramuscular injection (i.m.)

Monkey Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: The secretion of IFN-y stimulated CD4+ Th cell lines and rgp120-stimulated PBL from the vaccinated monkeys suggest that an HIV-1 env plasmid DNA vaccine elicits a Thl-like immune response in primates as well as in rodents (Lekutis et al., 1997)
• Efficacy: The secondary immune response that arose after repeated plasmid DNA administration was Thl-like, suggesting that the nature of the DNA vaccine-elicited Th cell response was maturation dependent. Evidence from vaccinated nonhuman primates suggests that a vigorous Th cell response, including viral Ag-specific IFN-y production, may be a correlate of protection from HIV- 1 and Simian Human Immunodeficiency Virus infection (Lekutis et al., 1997)