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Vaccine Detail
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Rabies Vaccine Adsorbed (RVA) |
| Vaccine Information |
- Vaccine Name: Rabies Vaccine Adsorbed (RVA)
- Target Pathogen: Rabies virus
- Target Disease: Rabies
- Product Name: Rabies Vaccine Adsorbed
- Tradename: None
- Manufacturer: BioPort Corp
- Vaccine Ontology ID: VO_0000095
- Type: Inactivated or "killed" vaccine
- Status: Licensed
- Location Licensed: USA
- Host Species for Licensed Use: Human
- Antigen: Inactivated Kissling strain of Challenge Virus Standard (CVS) rabies virus.
- Adjuvant:
- Adjuvant name:
- VO adjuvant ID: VO_0000128
- Description: BioPort's Rabies Vaccine is effective for pre- and post-exposure indications, and is administered intramuscularly (not intradermally). However, this vaccine is no longer available for rabies postexposure or pre-exposure prophylaxis, and intradermal pre-exposure prophylaxis is no longer recommended because it is not available in the United States (Manning et al., 2008).
- Preparation: Rabies Vaccine Adsorbed (RVA) is an aqueous formulation of rabies virus cultured in diploid fetal rhesus lung (FRhL-2) cells, inactivated with beta-propiolactone (BPL), and adsorbed on aluminum phosphate adjuvant. The vaccine is prepared from the Kissling strain of Challenge Virus Standard (CVS) rabies virus adapted to fetal rhesus lung diploid cell culture. The inactivated virus is concentrated by adsorption onto aluminum phosphate adjuvant.
- Description: BioPort's Rabies Vaccine is effective for pre- and post-exposure indications, and is administered intramuscularly (not intradermally). However, this vaccine is no longer available for rabies postexposure or pre-exposure prophylaxis, and intradermal pre-exposure prophylaxis is no longer recommended because it is not available in the United States (Manning et al., 2008).
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| Host Response |
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| References |
Manning et al., 2008: Manning SE, Rupprecht CE, Fishbein D, Hanlon CA, Lumlertdacha B, Guerra M, Meltzer MI, Dhankhar P, Vaidya SA, Jenkins SR, Sun B, Hull HF. Human rabies prevention--United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control. 2008; 57(RR-3); 1-28. [PubMed: 18496505].
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