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Vaccine Detail
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Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDF encoding gD |
| Vaccine Information |
- Vaccine Name: Bovine herpesvirus 1 recombinant vector vaccine rLaSota/gDF encoding gD
- Target Pathogen: Bovine herpesvirus 1
- Target Disease: Infectious bovine rhinotracheitis
- Vaccine Ontology ID: VO_0004319
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Calves
- US6
gene engineering:
- Type: Recombinant vector construction
- Description: Vector pLaSota expressed a chimeric gD in which the ectodomain of gD was fused with the transmembrane domain and cytoplasmic tail of the NDV fusion F glycoprotein (Khattar et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: combined IN and IT routes
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| Host Response |
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Cattle Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Following challenge with BHV-1, calves immunized with the recombinant NDVs had lower titers and earlier clearance of challenge virus compared to the empty vector control. Partial protection was observed (Khattar et al., 2010).
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| References |
Khattar et al., 2010: Khattar SK, Collins PL, Samal SK. Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody responses and provides partial protection against BHV-1. Vaccine. 2010; 28(18); 3159-3170. [PubMed: 20189484].
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