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Vaccine Detail

Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB
Vaccine Information
  • Vaccine Name: Bovine herpesvirus 1 DNA vaccine pMASIAtgB encoding a truncated, secreted form of gB
  • Target Pathogen: Bovine herpesvirus 1
  • Target Disease: Infectious bovine rhinotracheitis
  • Vaccine Ontology ID: VO_0004317
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mice, calves
  • gB gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pMASIA expressed truncated, secreted form of BHV-1 gB (Huang et al., 2005).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000284
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Cattle Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: pMASIAtgB elicited both humoral responses and activated gamma interferon-secreting CD8+ CTLs, suggesting that a DNA vaccine expressing tgB induces a CTL response in the natural host of BHV-1 (Huang et al., 2005).
References
Huang et al., 2005: Huang Y, Babiuk LA, van Drunen Littel-van den Hurk S. Immunization with a bovine herpesvirus 1 glycoprotein B DNA vaccine induces cytotoxic T-lymphocyte responses in mice and cattle. The Journal of general virology. 2005; 86(Pt 4); 887-898. [PubMed: 15784883].