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Vaccine Detail

Borrelia burgdorferi fla mutant vaccine
Vaccine Information
  • Vaccine Name: Borrelia burgdorferi fla mutant vaccine
  • Target Pathogen: Borrelia burgdorferi
  • Target Disease: Lyme Disease
  • Vaccine Ontology ID: VO_0002809
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • fla gene engineering:
    • Type: Gene mutation
    • Description: This fla mutant is from Borrelia burgdorferi (Sadziene et al., 1996).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intradermal injection (i.d.)
Host Response

Mouse Response

  • Persistence: A fla mutant is attenuated in SCID mice (Sadziene et al., 1996).
  • Efficacy: A fla mutant induces protection in mice from challenge with wild type B. burgdorferi 28 days after inoculation (Sadziene et al., 1996).
References
Sadziene et al., 1996: Sadziene A, Thompson PA, Barbour AG. A flagella-less mutant of Borrelia burgdorferi as a live attenuated vaccine in the murine model of Lyme disease. The Journal of infectious diseases. 1996; 173(5); 1184-1193. [PubMed: 8627071].