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Vaccine Detail

Bovine herpesvirus 1 US8 (gE) mutant vaccine
Vaccine Information
  • Vaccine Name: Bovine herpesvirus 1 US8 (gE) mutant vaccine
  • Target Pathogen: Bovine herpesvirus 1
  • Target Disease: Infectious bovine rhinotracheitis
  • Vaccine Ontology ID: VO_0002950
  • Type: Live, attenuated vaccine
  • Status: Research
  • US8 gene engineering:
    • Type: Gene mutation
    • Description:
    • Detailed Gene Information: Click Here.
  • Preparation: The bovine herpesvirus 1 (BHV1) strain Za is a conventionally attenuated strain with a 2.7 kb deletion that encompasses the complete coding region for glycoprotein E (gE) (Kaashoek et al., 1995).
  • Immunization Route: intranasal immunization
Host Response

Cattle Response

  • Persistence: The bovine herpesvirus 1 (BHV1) strain Za is a conventionally attenuated strain with a 2.7 kb deletion that encompasses the complete coding region for glycoprotein E (gE) (Kaashoek et al., 1995).
  • Efficacy: Calves given the vaccine with the highest antigen concentration were ad.equately protected against challenge; clinical symptoms were virtually absent and challenge virus shedding was significantly reduced as compared with unvaccinated calves (Kaashoek et al., 1995)
References
Kaashoek et al., 1995: Kaashoek MJ, Moerman A, Madić J, Weerdmeester K, Maris-Veldhuis M, Rijsewijk FA, van Oirschot JT. An inactivated vaccine based on a glycoprotein E-negative strain of bovine herpesvirus 1 induces protective immunity and allows serological differentiation. Vaccine. 1995; 13(4); 342-346. [PubMed: 7793128].