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Vaccine Detail
Bovine herpesvirus 1 US8 (gE) mutant vaccine |
Vaccine Information |
- Vaccine Name: Bovine herpesvirus 1 US8 (gE) mutant vaccine
- Target Pathogen: Bovine herpesvirus 1
- Target Disease: Infectious bovine rhinotracheitis
- Vaccine Ontology ID: VO_0002950
- Type: Live, attenuated vaccine
- Status: Research
- US8
gene engineering:
- Type: Gene mutation
- Description:
- Detailed Gene Information: Click Here.
- Preparation: The bovine herpesvirus 1 (BHV1) strain Za is a conventionally attenuated strain with a 2.7 kb deletion that encompasses the complete coding region for glycoprotein E (gE) (Kaashoek et al., 1995).
- Immunization Route: intranasal immunization
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Host Response |
Cattle Response
- Persistence: The bovine herpesvirus 1 (BHV1) strain Za is a conventionally attenuated strain with a 2.7 kb deletion that encompasses the complete coding region for glycoprotein E (gE) (Kaashoek et al., 1995).
- Efficacy: Calves given the vaccine with the highest antigen concentration were ad.equately protected against challenge; clinical symptoms were virtually absent and challenge virus shedding was significantly reduced as compared with unvaccinated calves (Kaashoek et al., 1995)
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References |
Kaashoek et al., 1995: Kaashoek MJ, Moerman A, Madić J, Weerdmeester K, Maris-Veldhuis M, Rijsewijk FA, van Oirschot JT. An inactivated vaccine based on a glycoprotein E-negative strain of bovine herpesvirus 1 induces protective immunity and allows serological differentiation. Vaccine. 1995; 13(4); 342-346. [PubMed: 7793128].
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