• Vaccine Name: Salmonella Typhimurium IppB/msbB mutant vaccine
• Target Pathogen: Salmonella spp.
• Target Disease: Salmonellosis
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• lppB gene engineering:
  • Type: Gene mutation
  • Description: This IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
  • Detailed Gene Information: Click Here.
• msbB gene engineering:
  • Type: Gene mutation
  • Description: This IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Persistence: An IppB/msbB mutant is attenuated in mice (Liu et al., 2008).
• Efficacy: An IppB/msbB mutant provides significant protection from challenge with wild type S. Typhimurium (Liu et al., 2008).
• Host Ighg1 response
  • Description: This mutant elicited a significantly greater serum IgG1 response compared to infection with the wild type on day 14 after vaccination. Peak levels were reached five days after infection (Liu et al., 2008).
  • Detailed Gene Information: Click Here.
• Host IL-6 response
  • Description: Culture supernatants from T cells infected with the lppB/msbB mutant contained significantly higher levels of IL-6 than did supernatants from T cells that were infected with WT S. Typhimurium (Liu et al., 2008).
  • Detailed Gene Information: Click Here.