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Vaccine Detail

Brucella melitensis mucR mutant vaccine

Vaccine Information

Vaccine Name: Brucella melitensis mucR mutant vaccine
Target Pathogen: Brucella spp.
Target Disease: Brucellosis
Vaccine Ontology ID: VO_0004277
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: mouse
mucR gene engineering:
- Type: Gene mutation
- Description: This gene is mutated in the B. melitensis 16M mucR mutant (Arenas-Gamboa et al., 2011).
- Detailed Gene Information: Click Here.
Immunization Route: Intramuscular injection (i.m.)

Host Response

Mouse Response

Persistence: A mucR mutant has a significantly reduced degree of colonization in mice (Arenas-Gamboa et al., 2011).
Efficacy: A mucR mutant of 16M protected against challenge with wild type B. melitensis 16M (Arenas-Gamboa et al., 2011).

References

Arenas-Gamboa et al., 2011: Arenas-Gamboa AM, Rice-Ficht AC, Kahl-McDonagh MM, Ficht TA. The protective efficacy and safety of 16M{Delta}mucR against intraperitoneal and aerosol challenge in BALB/c mice. Infection and immunity. 2011; ; . [PubMed: 21708998].