• Vaccine Name: pneumococcal polysaccharide conjugate vaccine serotype 1 (PNC-1)
• Target Pathogen: Streptococcus pneumoniae
• Target Disease: Pneumonia
• Vaccine Ontology ID: VO_0004265
• Type: Conjugate vaccine
• Status: Research
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001344
• Immunization Route: intranasal immunization

Mouse Response

• Host Strain: NMRI
• Vaccination Protocol: Mice were immunized i.n. with 0.5 or 2.0 μg of PNC-1 alone or mixed with either LT-K63 or LT-R72 (Jakobsen et al., 1999).
• Immune Response: Administration of PNC-1 i.n. with either LT-K63 or LT-R72 elicited significantly higher antibody responses than the s.c. route for both 0.5- and 2.0-μg doses of PNC-1 in saline (Jakobsen et al., 1999).
• Challenge Protocol: Mice were challenged with 50 μl of pneumococcal suspension i.n. and were allowed to aspirate it into the lungs for 10 min (Jakobsen et al., 1999).
• Efficacy: Immunization i.n. with PNC-1 and LT-K63 or LT-R72 conferred 100% clearance of lung infection caused by serotype 1 pneumococci (Jakobsen et al., 1999).