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Vaccine Detail

gp140, Gag and Tat Protein Vaccine with MF59
Vaccine Information
  • Vaccine Name: gp140, Gag and Tat Protein Vaccine with MF59
  • Target Pathogen: Human Immunodeficiency Virus
  • Target Disease: Acquired Immunodeficiency Syndrome (AIDS)
  • Vaccine Ontology ID: VO_0004238
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: gp140, Gag and Tat recombinant proteins (Bråve et al., 2007).
  • Adjuvant:
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Host Strain: C57Bl/6
  • Vaccination Protocol: The protein vaccine component consisted of 20 μg ro-gp140 delivered in the right tibialis muscle and 20 μg rGag and 5 μg rTat delivered in the left tibialis muscle. The proteins were formulated in 50% MF59 solution. Mock treatment consisted of MF59 adjuvant alone or empty DNA plasmid alone (Bråve et al., 2007).
  • Challenge Protocol: Briefly, 3 weeks after the final immunization (week 12), the animals were injected intraperitoneally with 1 million syngeneic splenocytes infected with HIV-1/MuLV of subtype B (LAI) (Bråve et al., 2007).
  • Efficacy: 83% of mice were tested negative for HIV-1 after challenge (Bråve et al., 2007).
References
Bråve et al., 2007: Bråve A, Hinkula J, Cafaro A, Eriksson LE, Srivastava IK, Magnani M, Ensoli B, Barnett SW, Wahren B, Rollman E. Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge. Vaccine. 2007; 25(39-40); 6882-6890. [PubMed: 17707956].