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Vaccine Detail

Salmonella vacT
Vaccine Information
  • Vaccine Name: Salmonella vacT
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Tradename: vacT
  • Vaccine Ontology ID: VO_0004142
  • Type: Live, attenuated vaccine
  • Antigen: Salmonella vacT is made of S. Typhimurium (Methner et al., 1997).
Host Response

Chicken Response

  • Vaccination Protocol: A group of one-day-old SPF chicks were innoculated orally with 0.1 ml of a vacT culture such that each bird received between 6 x 10^8 and 1 x 10^9 cfu each (Methner et al., 1997).
  • Challenge Protocol: The birds were challenged 24 h later orally with 0.1 ml of nalidixic acid-resistant Salmonella derivative diluted in PBS such that each bird recieved 10^4 cfu (Methner et al., 1997).
  • Efficacy: A significant amount of S. Typhimurium 421 was found in the livers and the caeca of the birds days after the challenge (Methner et al., 1997).
References
Methner et al., 1997: Methner U, Barrow PA, Martin G, Meyer H. Comparative study of the protective effect against Salmonella colonisation in newly hatched SPF chickens using live, attenuated Salmonella vaccine strains, wild-type Salmonella strains or a competitive exclusion product. International journal of food microbiology. 1997; 35(3); 223-230. [PubMed: 9105931].