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Vaccine Detail
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Zoosaloral H. |
| Vaccine Information |
- Vaccine Name: Zoosaloral H.
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Tradename: Zoosaloral H.
- Vaccine Ontology ID: VO_0004141
- Type: Live, attenuated vaccine
- Antigen: The antigen is a strain of S. Typhimurium called Zoosaloral H.
- Preparation: This live vaccine strain is derived by chemical mutagenesis from a virulent avian S. Typhimurium DT009 isolate. Chemical mutagenesis caused attenuation via adenine and histidine auxotrophy, but did not change the phage type of the vaccine strain (Frech et al., 1998).
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| Host Response |
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Chicken Response
- Vaccination Protocol: One-day-old SPF chickens were inoculated orally with 0.1 ml of a Zoosaloral culture such that the birds received between 6 x 10^8 and 1 x 10^9 cfu each (Methner et al., 1997).
- Persistence: Not noted.
- Challenge Protocol: The birds were challenged 24 h later orally with 0.1 ml of a culture of nalidixic acid-resistant Salmonella derivative diluted in PBS such that each bird received 10^4 cfu(Methner et al., 1997).
- Efficacy: A significant amount of S. Typhimurium 421 was fund in the livers of the chickens after pretreatment and challenge (Methner et al., 1997).
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| References |
Frech et al., 1998: Frech G, Weide-Botjes M, Nussbeck E, Rabsch W, Schwarz S. Molecular characterization of Salmonella enterica subsp. enterica serovar Typhimurium DT009 isolates: differentiation of the live vaccine strain Zoosaloral from field isolates. FEMS microbiology letters. 1998; 167(2); 263-269. [PubMed: 9809427].
Methner et al., 1997: Methner U, Barrow PA, Martin G, Meyer H. Comparative study of the protective effect against Salmonella colonisation in newly hatched SPF chickens using live, attenuated Salmonella vaccine strains, wild-type Salmonella strains or a competitive exclusion product. International journal of food microbiology. 1997; 35(3); 223-230. [PubMed: 9105931].
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