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Vaccine Detail
Salmonella IroN Protein Vaccine |
Vaccine Information |
- Vaccine Name: Salmonella IroN Protein Vaccine
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Vaccine Ontology ID: VO_0004184
- Type: Subunit vaccine
- Status: Research
- IroN
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Adjuvant:
- Immunization Route: Intramuscular injection (i.m.)
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Host Response |
Chicken Response
- Host Strain: white leghorn
- Vaccination Protocol: Ten 30-day-old specific-pathogen-free (SPF) white leghorn chickens were immunized intramuscularly with 0.5 ml of purified IroN (0.05 mg/ml), homogenized with Freund's incomplete adjuvant, and 10 control chickens were immunized intramuscularly with PBS homogenized with Freund's incomplete adjuvant. The immunized chickens were given an intramuscular booster injection 3 wk after the first immunization (Kaneshige et al., 2009).
- Challenge Protocol: Three weeks after the second injection, the immunized chickens and controls were challenged intravenously with 10^8 CFU of Salmonella Enteritidis (Kaneshige et al., 2009).
- Efficacy: The mortality rate of immunized chickens was 10%, while that of control chickens was 80% (Kaneshige et al., 2009).
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References |
Kaneshige et al., 2009: Kaneshige T, Yaguchi K, Ohgitani T. Siderophore receptor IroN is an important protective antigen against Salmonella infection in chickens. Avian diseases. 2009; 53(4); 563-567. [PubMed: 20095157].
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