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Vaccine Comparison
P. multocida DNA vaccine pcDNA-OMPH + pcDNA-OMPA |
P. multocida DNA vaccine pcDNA-OMPH/OMPA |
Vaccine Information |
Vaccine Information |
- Vaccine Ontology ID: VO_0004536
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chickens
- OmpA
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- ompH
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Vector: pcDNA3.1(+) (Gong et al., 2013)
- Immunization Route: Intramuscular injection (i.m.)
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- Vaccine Ontology ID: VO_0004537
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chickens
- OmpA
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- ompH
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Vector: pcDNA3.1(+) (Gong et al., 2013)
- Immunization Route: Intramuscular injection (i.m.)
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Host Response |
Host Response |
Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: A significant increase in serum antibody levels was observed in chickens vaccinated with divalent combination. Additionally, the lymphocyte proliferation (SI value) and the levels of IFN-γ were both higher in chickens immunized with divalent combination than in those vaccinated with monovalent DNA vaccines (P<0.05) (Gong et al., 2013).
- Efficacy: The protection provided by divalent combination vaccine was superior to that provided by monovalent DNA vaccines after challenging with the avian P. multocida strain CVCC474 (Gong et al., 2013).
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Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: A significant increase in serum antibody levels was observed in chickens vaccinated with the fusion DNA vaccine. Additionally, the lymphocyte proliferation (SI value) and the levels of IFN-γ were both higher in chickens immunized with the fusion DNA vaccine than in those vaccinated with monovalent DNA vaccines (P<0.05) (Gong et al., 2013).
- Efficacy: Protection provided by the fusion DNA vaccine was superior to that provided by monovalent DNA vaccines after challenging with the avian P. multocida strain CVCC474. The protective efficacy in chickens immunized three times with the fusion DNA vaccine was equivalent to the protective efficacy in chickens vaccinated once with the attenuated live vaccine (Gong et al., 2013).
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References |
References |
Gong et al., 2013: Gong Q, Qu N, Niu M, Qin C, Cheng M, Sun X, Zhang A. Immune responses and protective efficacy of a novel DNA vaccine encoding outer membrane protein of avian Pasteurella multocida. Veterinary immunology and immunopathology. 2013; 152(3-4); 317-324. [PubMed: 23340446].
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Gong et al., 2013: Gong Q, Qu N, Niu M, Qin C, Cheng M, Sun X, Zhang A. Immune responses and protective efficacy of a novel DNA vaccine encoding outer membrane protein of avian Pasteurella multocida. Veterinary immunology and immunopathology. 2013; 152(3-4); 317-324. [PubMed: 23340446].
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