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Vaccine Detail

Ad5-RSV-F
Vaccine Information
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: None
  • Preparation: Adenovirus serotype 5-based RSV vaccine encoding the fusion (F) protein (Ad5.RSV-F)(Kim et al., 2014)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Rat Response

  • Vaccination Protocol: Animals were immunized intranasally (i.n.) and/or intramuscularly (i.m.) with Ad5.RSV-F (Kim et al., 2014)
  • Challenge Protocol: (Kim et al., 2014)Post vaccination, animals were subsequently challenged with RSV/A/Tracy (i.n.)
  • Efficacy: (Kim et al., 2014)The vaccine provided protective immunity against RSV challenge without enhanced lung disease in the rats
References
Kim et al., 2014: Kim E, Okada K, Beeler JA, Crim RL, Piedra PA, Gilbert BE, Gambotto A. Development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model. Journal of virology. 2014; 88(9); 5100-5108. [PubMed: 24574396].