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Murine cytomegalovirus DNA vaccine pcDNA-89 encoding pp89 |
Murine cytomegalovirus DNA vaccine pgM-pgN |
| Vaccine Information |
Vaccine Information |
- Vaccine Ontology ID: VO_0004323
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- IE1
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNAI/Amp expressed the murine cytomegalovirus (MCMV) immediate-early gene 1 (IE1) encodes an 89-kDa phosphoprotein (pp89) (González et al., 1996).
- Detailed Gene Information: Click Here.
- Vector: pcDNAI/Amp (González et al., 1996)
- Immunization Route: Intradermal injection (i.d.)
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- Vaccine Ontology ID: VO_0004526
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: gM and gN from murine cytomegalovirus strain Smith (Wang et al., 2013)
- gM
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- gN
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Vector: pcDNA3.1 (Wang et al., 2013)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: In four separate trials, an average of 63% of the mice immunized with pcDNA-89 survived after lethal challenge, compared with 18% of the mice immunized with pcDNA (control) (González et al., 1996).
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Co-immunization with pgM and pgN three times at a high dose was able to provide mice with full protection against a lethal SG-MCMV challenge with a 100% survival rate. The protection obtained with the gM-gN co-immunization was far greater than each antigen alone (Wang et al., 2013).
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| References |
References |
González et al., 1996: González Armas JC, Morello CS, Cranmer LD, Spector DH. DNA immunization confers protection against murine cytomegalovirus infection. Journal of virology. 1996; 70(11); 7921-7928. [PubMed: 8892915].
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Wang et al., 2013: Wang H, Yao Y, Huang C, Chen Q, Chen J, Chen Z. Immunization with cytomegalovirus envelope glycoprotein M and glycoprotein N DNA vaccines can provide mice with complete protection against a lethal murine cytomegalovirus challenge. Virologica Sinica. 2013; ; . [PubMed: 23715998].
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