VIOLIN: Vaccine Investigation and Online Information Network

Vaccine Comparison

Equid herpesvirus gE mutant vaccine	Equid herpesvirus gI mutant vaccine	Equid herpesvirus TK mutant vaccine
Vaccine Information	Vaccine Information	Vaccine Information
Vaccine Ontology ID: VO_0002955 Type: Live, attenuated vaccine Status: Research Host Species as Laboratory Animal Model: Mouse gE gene engineering: Type: Gene mutation Description: This gE mutant is from Equid herpesvirus 1 (Tsujimura et al., 2006). Detailed Gene Information: Click Here. Immunization Route: intranasal immunization	Vaccine Ontology ID: VO_0002956 Type: Live, attenuated vaccine Status: Research Host Species as Laboratory Animal Model: Mouse gI gene engineering: Type: Gene mutation Description: This gI mutant is from Equid herpesvirus 1 (Tsujimura et al., 2006). Detailed Gene Information: Click Here. Immunization Route: intranasal immunization	Product Name: PR1 Vaccine Ontology ID: VO_0002957 Type: Live, attenuated vaccine Status: Research Host Species as Laboratory Animal Model: Mouse, horse TK gene engineering: Type: Gene mutation Description: This TK mutant is from Equid herpesvirus 1 (Slater et al., 1993). Detailed Gene Information: Click Here. Immunization Route: intranasal immunization
Host Response	Host Response	Host Response
Mouse Response Persistence: A gE mutant is attenuated in mice (Tsujimura et al., 2006). Efficacy: A gE mutant induces significant protection in mice from challenge with wild type EHV (Tsujimura et al., 2006).	Mouse Response Persistence: A gI mutant is attenuated in mice (Tsujimura et al., 2006) Efficacy: A gI mutant induces significant protection in mice from challenge with wild type EHV (Tsujimura et al., 2006).	Mouse Response Persistence: A TK mutant is attenuated in mice (Slater et al., 1993). Efficacy: A TK mutant induces significant protection from challenge with wild type EHV (Slater et al., 1993).
		Horse Response Persistence: A TK mutant is attenuated in foals (Slater et al., 1993). Efficacy: A TK mutant provides partial protection in foals from challenge with wild type EHV (Slater et al., 1993).
References	References	References
*Tsujimura et al., 2006:* Tsujimura K, Yamanaka T, Kondo T, Fukushi H, Matsumura T. Pathogenicity and immunogenicity of equine herpesvirus type 1 mutants defective in either gI or gE gene in murine and hamster models. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2006; 68(10); 1029-1038. [PubMed: 17085880].	*Tsujimura et al., 2006:* Tsujimura K, Yamanaka T, Kondo T, Fukushi H, Matsumura T. Pathogenicity and immunogenicity of equine herpesvirus type 1 mutants defective in either gI or gE gene in murine and hamster models. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 2006; 68(10); 1029-1038. [PubMed: 17085880].	*Slater et al., 1993:* Slater JD, Gibson JS, Field HJ. Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals. The Journal of general virology. 1993; 74 ( Pt 5); 819-828. [PubMed: 8388018].