• Vaccine Ontology ID: VO_0004414
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• TTC gene engineering:
  • Type: Recombinant protein preparation
  • Description: Vector pcDNA3 expressed fragment C (Anderson et al., 1997).
  • Detailed Gene Information: Click Here.
• Vector: pcDNA3 (Anderson et al., 1997)
• Immunization Route: Intramuscular injection (i.m.)

• Vaccine Ontology ID: VO_0004230
• Type: Toxoid vaccine
• Status: Research
• Adjuvant:
  • VO ID: VO_0000131
• Preservative: Thimerosal (Gupta and Siber, 1994).
• Immunization Route: subcutaneous injection

• Vaccine Ontology ID: VO_0004231
• Type: Toxoid vaccine
• Status: Research
• Adjuvant:
  • VO ID: VO_0001316
• Preservative: Thimerosal
• Immunization Route: subcutaneous injection

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: Anti-Fragment C serum immunoglobulin and proliferative responses in splenocytes were observed following two immunizations with pcDNA3/tetC (Anderson et al., 1997).
• Efficacy: Immunization of mice with Fragment C protein, the non-toxic C-terminal domain of tetanus toxin, protects mice against lethal challenge with tetanus toxin. Seven out of ten immunized mice were protected (Anderson et al., 1997).

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: MIce were injected with TT preparation subcutaneously and boosted 30 days later (Gupta and Siber, 1994)
• Immune Response: Mice immunized with CP-TT had IgG levels than mice immunized with TT adsorbed to aluminum phosphate (Gupta and Siber, 1994).

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Mice were injected with TT preparation subcutaneously and boosted 30 days later (Gupta and Siber, 1994).
• Immune Response: Mice immunized with stearyl tyrosine TT had lower IgG responses than in mice immunized with TT adsorbed to aluminum phosphate (Gupta and Siber, 1994).