- Vaccine Ontology ID: VO_0004512
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Water buffalo
- Sj23
gene engineering:
- Type: DNA vaccine construction
- Description: pVAX1 expressed SjC23 (Da'dara et al., 2008).
- Detailed Gene Information: Click Here.
- Vector: pVAX1 (Da'dara et al., 2008)
- Immunization Route: Intramuscular injection (i.m.)
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- Vaccine Ontology ID: VO_0004511
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Water buffalo
- Sj23
gene engineering:
- Type: DNA vaccine construction
- Description: pVAX1 expressed SjC23 and bovine heat shock protein 70 (Da'dara et al., 2008).
- Detailed Gene Information: Click Here.
- Vector: pVAX1 (Da'dara et al., 2008)
- Immunization Route: Intramuscular injection (i.m.)
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- Vaccine Ontology ID: VO_0004458
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Water buffalo
- TPI
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine expressed triose-phosphate isomerase (SjCTPI) (Da'dara et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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- Vaccine Ontology ID: VO_0004459
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Water buffalo
- TPI
gene engineering:
- Type: DNA vaccine construction
- Description: This DNA vaccine expressed triose-phosphate isomerase (SjCTPI) fused to bovine heat shock protein 70 (Da'dara et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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Water buffalo Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: This vaccine reduced worm burdens by 45.5% and fecal miracidial hatching by 47.4% after challenge (Da'dara et al., 2008).
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Water buffalo Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Worm burdens were reduced by 50.9% and fecal miracidial hatching by 52.0% after challenge (Da'dara et al., 2008).
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Water buffalo Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Worm burdens were reduced by 41.5% and fecal miracidial hatching were reduced by 33.2% (Da'dara et al., 2008).
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Water buffalo Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: This vaccine produced a 51.2% reduction in worm burden, 61.5% liver egg reduction, 52.1% fecal egg reduction and 52.1% reduction in fecal miracidia (Da'dara et al., 2008).
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Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
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Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
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Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
|
Da'dara et al., 2008: Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine. 2008; 26(29-30); 3617-3625. [PubMed: 18524429].
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