• Vaccine Ontology ID: VO_0011378
• Type: DNA vaccine
• Status: Research
• Antigen: Bovine leukemia virus envelope gene encoding extracellular glycoprotein gp51and transmembrane glycoprotein gp30
• Env/Rex/Tax gene engineering:
  • Type: DNA vaccine construction
  • Description: The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 (encoded by env gene) and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter (Brillowska et al., 1999).
  • Detailed Gene Information: Click Here.
• Vector: pcDNA3 (Brillowska et al., 1999)
• Immunization Route: Intramuscular injection (i.m.)

Cattle Response

• Efficacy: The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (Brillowska et al., 1999).