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Experimental autoimmune encephalomyelitis

Table of Contents
  1. General Information
    1. Disease
    2. Introduction
  2. Vaccine Related Pathogen Genes
    1. Mog (Other)
    2. MBP (Protective antigen)
    3. Mog (Protective antigen)
  3. Vaccine Information
    1. EAE DNA vaccine pZZ/MBP68–85 encoding MBP
  4. References
I. General Information
1. Disease:
Experimental autoimmune encephalomyelitis (EAE)
2. Introduction
The experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE) is an animal model of brain inflammation. It is an inflammatory demyelinating disease of the central nervous system (CNS). It is mostly used with rodents and is widely studied as an animal model of the human CNS demyelinating diseases, including multiple sclerosis and acute disseminated encephalomyelitis (ADEM). EAE is also the prototype for T-cell-mediated autoimmune disease in general. EAE was motivated by observations during the convalescence from viral diseases by Thomas M. Rivers, D. H. Sprunt and G. P. Berry in 1933. Their findings upon a transfer of inflamed patient tissue to primates was published in the Journal of Experimental Medicine article (Vol. 58, No. 1, pp. 39–56). An acute monophasic illness, it has been suggested that EAE is far more similar to ADEM than MS. EAE can be induced in a number of species, including mice, rats, guinea pigs, rabbits and primates. The most commonly used antigens in rodents are spinal cord homogenate (SCH), purified myelin, myelin protein such as MBP, PLP and MOG, or peptides of these proteins, all resulting in distinct models with different disease characteristics regarding both immunology and pathology. It may also be induced by the passive transfer of T cells specifically reactive to these myelin antigens. Depending on the antigen used and the genetic make-up of the animal, rodents can display a monophasic bout of EAE, a relapsing-remitting form, or chronic EAE . The typical susceptible rodent will debut with clinical symptoms around two weeks after immunization and present with a relapsing-remitting disease. The archetypical first clinical symptom is weakness of tail tonus that progresses to paralysis of the tail, followed by a progression up the body to affect the hind limbs and finally the forelimbs. However, similar to MS, the disease symptoms reflect the anatomical location of the inflammatory lesions, and may also include emotional lability, sensory loss, optic neuritis, difficulties with coordination and balance (ataxia), and muscle weakness and spasms. Recovery from symptoms can be complete or partial and the time varies with symptoms and disease severity. Depending on the relapse-remission intervals, rats can have up to 3 bouts of disease within an experimental period (Wiki: Experimental autoimmune encephalomyelitis).
1. MBP
  • Gene Name : MBP
  • Sequence Strain (Species/Organism) : Cavia porcellus
  • NCBI Protein GI : 3309629
  • Other Database IDs : CDD:279937
  • Taxonomy ID : 10141
  • Gene Strand (Orientation) : ?
  • Protein Name : myelin basic protein
  • Protein pI : 11.21
  • Protein Weight : 16394.29
  • Protein Length : 214
  • Protein Note : MBP
  • Protein Sequence : Show Sequence 
    >AAC26130.1 myelin basic protein, partial [Cavia porcellus]
SQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGSDRAAPKRGSGKDSHHAARTTHYGSLPQKS
QRSQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGGRADYKSKGFKGAHDAQGT
LSKIFKLGGR
  • Molecule Role : Protective antigen
  • Related Vaccine(s): EAE DNA vaccine pZZ/MBP68–85 encoding MBP
2. Mog
  • Gene Name : Mog
  • Sequence Strain (Species/Organism) : Mus musculus
  • NCBI Gene ID : 17441
  • NCBI Protein GI : 113199771
  • Genbank Accession : AC116130
  • Protein Accession : NP_034944
  • Taxonomy ID : 10090
  • Chromosome No : 17
  • Gene Starting Position : 37010739
  • Gene Ending Position : 37023397
  • Gene Strand (Orientation) : -
  • Protein Name : transcript variant X1
  • Protein pI : 8.06
  • Protein Weight : 26389.6
  • Protein Length : 247
  • Protein Note : Also known as B230317G11Rik
  • DNA Sequence : Show Sequence 
    >NC_000083.6:37010739-37023397 Mus musculus strain C57BL/6J chromosome 17, GRCm38.p4 C57BL/6J
GAAGTATGCACAGAGAAACTTGTATTATTAATTAGCACCTAGCTTGTTTGTGTCTGGTAGACCACCAAGT
AGTAATTTTTGGGGGAAAAAAACCACATTGGTTCTCAGAGAAATAAGGTAGGAGAAAATGAGAGGCAGGG
GTATGAAGGGCACGAAGGTGTGGAACATAGGGGAGCAGACCCAGTTCTCAGCCCTTGCTTCTCAAGGTCC
TCCCACCAGGCTGCCAAAGCAAGATGGTATTTCTCTGGTCGGTATTCTTTTGAATTTTAGCTCCAGGTTT
TGGTTCAGGTGCTCATATTCATACCCTGGCTCACTTAGCTTTCCCCGATATTGTGGGCTCTTCTGTTCCT
GACCCCCCCCCCCCCACATTGATATTCTTCCCAGTCAAGGCTGTGGTCTTGGAAGAAATATCCACCATTT
GCAGAGTTGATGTTCTATAGTTCACAATGATGAAGTGCTGCGTATCCTGGTTGGCAGAATCACTCCTGTA
TTACTCTGGTGCATAGGTGTCTCCTGATAGACTGCCTGGCCTTCACCACAGGGTGTTTTCTATAGTCAGA
CTAACATGGTAAAAAAGATGTGGAAGTCAAAAATTAGAGGAAGGAGCTGAGGAAAGACAGTTGAGGGAGG
GAAATCAAGTTCTACTCGGTATCCAGAATGTGTCTGTAGATGTAGATTGGAATCTGTCCACAGCAAAGAG
GCCAATGGGAAATCCCCAAGGACCTGCTGGGCTCTCCTTCCGCTCCAGGAAGACACAACCATCACTCAAA
AGGGGTTTCCTGGAAAGACAGACAAGTGACTTTAAAAACCTCTGCCAGTAGGTTCTTTTTATGAAGTCCT
TGAACCTAGGAGATAGAAAGTTCCTAGGGGTCATGTGATCTCTCCCCCAACCGCCTGGTTGGTCTTGGAG
GGAGGTGAGGTTCGGGATAACTATTATGGAGAATGTTAAAGGGGGCTGCAGAAGTGGAATTCTGGCTCAG
GGGCACTAAAGGCTATTAAGTCAACAGGTAAGAGTGGCTCAGCAGCCTCTCTGGCACTGAAAATGTGTCT
CGTTAATTCCCTCCCCTTTTCCCCTCACAAGAGGAGTCATTCCAGCCTTCCCTGGGATAATGGTCCCTCA
GTAACCATGTTCCCTTTGCTGGGTTTTTGTTCGATTTAGAAGGAGGGAAATGGTTGGGTACAATGGTATG
TGCTTAAGACGGTAACACTTGGAGGCAAGAAGAGGGTTGCCATAGTTTCTAGACCAGTTTGGTTTACATA
GTAAGTTCTAAGGCTGCATAATGAGATGTCTCAAGATTGGAGAGGGGTGTTAGGGAGAACTTACTTAGCT
CTTCAAGAAACTGTCCTGTAAACAAAAAGAAATGAGTCAATGGGTGGTCAGTGGGAGTCCCCCCTCACCT
CCCCAGACAACCCTCCCTCCCCATTAAGAGGCCTATACATCTCATTAAGTGGTTCTCCGTTTTCCTATGG
ATTCTGATGGTGAGAGTAAAGATTCCCATCCCTGGAATCTAGAACCTTGGTTCCACTCTTTTCCCATACT
GGTCTGCCTGAGTTCCCTGATGCATAGCAGTCCTGTTTTGCTGCCCAGACACCGAACCTGCCAGTCTTCG
GTGCAGCCAGTTGTAGCAGATGATCAAGGCAACCAGGGGTCCAAGAACAGGCACAATAACAAACAGTGTT
ATCTTCCAGCAGGGCACCCTCAGGAAGTGAGGATCTGAGGTAAAGCAGAGCAGAGTGTCTCCCTCTGTGC
CACGCCCATTCTTAACCTGAAGCCCCGAAATGACAAAGGACTCTGGGGACAGGCTGTAGAGTCCGTGAAC
ATGGCTGGGGTGCACTGTCCCTTTATTTTCATTAACTTCTGATTGAATTTAGCTTTTTAACTGATTTATC
ATAGAAAACAGGTTGTGTGACTTTTCATGCATTGTTTATGTTCAGCCATGCATTGACCCTCCCTCACCCC
AATCTCTAGCATTTTTATTTGTTTGAAGAGAGGTTCTTGCCCTGTATCCCTGGCTGGCCTTGAATTTGAG
AAATCCTGTCTCAGCCTTACAGGTGTTGTGGTTACAAGTCATCAAACCCTGCTTTCCCTAAGGTTTTCTT
TTTCTGTGTGGCAGAGGTTTATTTGGAGGTGGGGGTGGAGACAAAGGGACAAAGAGAAAAGGAAAAAACA
GGGCACGGTTTTCTTATACTAACAGACTAGGGATGCAGTCTCAAAAAGAAAGAAACCAGCAAAAACAAAA
AGTCAAAAACTGGTATTAGGACTGACTGTATGATTTTAAGATACAAACATGGTTAAGAACTTAGACATTC
AAATCTTTTTTTTTTTTTTTTTTTTTTGGAGGCAGGGTTTCTCTGTATAGCCCTGGCTGTCCTGGAACTC
ACTATGTAGACCAGGCTGGCCTCGAACTCAGAAATCCGCCTGCCTCTGCCTTCCAAGTGCTGGGATTAAA
GGTGTGTGCCACCACTGCCCGGCTAGACATTCAAACCTTATAAGTAAAATCCTGGGGGTTGGGAAGGTAG
CTCAGTTTGTAGAGCTCTGAGTTCCACCCCCAGCACAGCATGCACTAGGCTTGGTGGCTCACACTTATAA
TCCCAGAATATAGGAGGTGTAGGCAGGGGGATGATCAAAATTCAAGGTAATCTTTGGCTACATAGTGAGT
TTGAGTCCTTCCTGAAATACATGAGACAGACATTTCAAAACAAAATGGAAATGGGAACGGTGAGATGGTT
TAGCTGATAAAGGCACTTGCTGCTAAACCTGAAGACCTGAGTTTGACCCCAGACCCACATGATAGGAGAG
AACCAACTCCTTTATATTGTCCTCTGACCTCTGTGTGAGCACTTGCCCACACTCACCCACTCACACCCTC
CACACACACAATAAAATACATTCAAAGACTACATGTGTGATGTCCATATATTGGCCCAATGTCAAGTGCT
AGGGTGTAGCCAAGTACCAGGAGAGCTGAACAGGGTTGCATCTGGCTTCAGAAGGAAAGGCTGTTTATGT
TTAGGAAGATTGATTAGAGCAGGATTCTGCTATGCTCTGCTTAATGTTATTTTTTTAGTTGTGTGGAATC
TATTCAACAAACGTTTGGGTATTCTTCTGTTGCTGGTGTTGTCCTTAGGAACTCTGCAATCTGAAGTGAA
GAAAATGCGAAGATGATTCTTGAGGACTTAATATTCTAGTTGGGGCATGCATGGTTGAGTATACATTTAC
CAGAATCTTGGGAGTTGAAGGTAGAAGGAGAAGAAGTCCAAGGCCAACCTTCATGACATAGTGAGTTTGA
AGGCCAGCATAGCCATATGAAACCCTGACTCAAAAAGTTACTAGTGAGGTTTCATTTTCTCCTCAAAGAA
GACTTCCCTGTTGAATCATGTGCTTGGACTACATTCCTGAAAACTAACTCTGCCATATAAGTATAGCAGA
TGACTTTTTTTAAATGTAATTTTCTGGATATGGTGGCACATGTCTTTAATCCCAACACTGGGGAAGGAGA
GTGTGTGGAGCTCTGTAAGTTCAAAGCCAACCTGTTGTTCATAGTGAATTCCAGGTTAGCCAGGGCTACA
CAGTGAGACCATAACTTAAAATTTTTTTTCTTACATATGTATTCCTTGTGCATATAGCTGTTTGCTGTGG
GGTCAGGAAATGGAACTTTAGGTCCTCTAGGGGAGCAGCAGGTGCTCTTAACGATTTTTCCCACCAGCAA
GCAATTTTATGTGCAAAGGATCTCTTTAACCACTTTTTATAATTCAGAAGATGAATATATATACATATAT
ATACACATAAGTACATATATGCATGTATACATATAAAGTTTACAATTGGTAAAATTCAGTGTAGGGCCTG
ACACTGGAATATGGTACATTAATGATTGCTACATTCCTATAGATCTTGAATGTGAAGAAAAAAGGTGGAG
GGGCCTTACAAAAAGCCACTGGTTCTAGTCCCCCAGGCCACTAGTGAAGTCCCACGGTGACTTGGGAGGG
TTGGGATATGCCTGAACTTACCAAAAGTCCGATGGAGATTCTCTGAAAAGGACAAATAAGAATAGACTTA
GTAAGGAACTGAAAGGGAGTCCCTTCCTTGGATCTATCTAAATCCCTCAAGGTTGGTTCTAGCCCTGATG
CAAAGTAAACCGTGCTATAAGAGCTCGGGTGAAAAAAAAATCTAATTTTTAGCTGTCTATAGTCTTAAAT
ATAAAGTTCCCAATTGAAGGGAGCATGGAGCATTGGGGGAAAGGCAGAAATGGTCTGAAGAGAGGGATAT
TTTGGTTAAGTTATAAAGACCAGAAGAGGAATTGGGGAGGGAGGGTGTCTGGAACTCACCTACTTCTGCA
CGAAGTTTTCCTAAAATAGAAAAAAGCAGGTATTTTAGTTCCTGATCTAACAGTATGAGGACCCTTCCAT
ACCACCCAGCACCTTGGACCTTTGTGTGGAGAATTCTTTGATGGCCCGGGAGCATCTTAGAATAGGAAGA
GCTCTAGATTTGAAACCAAGAGTCCAGTCTCTTTCTGTGAATATTGTCTGATTAAATAATGAAATAAAGA
GCATGAGAGCCTGGAACTGATAGTGATTGGTTGCGTTGTCTGTCATCACAGCAAGGACAAGGCTGATTAT
GTCGATCTAGCTGGCTTCTTTTCTTACAACTCCGTATGTGTCCCTCCCAAAACTGTTTGCTTGGCTGGAG
AAAATGACCTTCCAGAAGAACAGGGCCCACTGTTCTTTGGTTACAGGTATAACAAATTGCTGCAGTTCAC
AACTGGAACCTCCAAACCTTTTTGCATTTAAGAATGCAAAAGTCTGGGGCTGGTGAGATGGCTCAGCAGG
TAAGAGCACTGACTGCTCTTCCGAAGGTCCTGAGTTCAAATCCCAGCAACCACATGGTGGCTCACAACCA
TCTATAACAAGACTGGATACCCTCTTCTGGTGTGTCTGAAGACAGCTACAGTGTACTTACATATCGTAAA
TAAATAAAGCTTAAAAAAAAAAAAAGCAAAAGTCTCAGGAACCTGCAATGTTCCTAACATACCACATGGT
TGGCTTGTTCTTCTTCTTTTATTTTTAATTCTATCTGTGTCGCAGTGAGTGTGTGCGTGTGTCTGTGCGT
ACACATGAGTATGTGTGCCCCTGGAGTCCAGAAAAGGTTGTCAGATCTCCTAATGTTATGGGTGGTTATG
AGTTGCCTGATAGGTGCTAGGGCTAGAACTTGAGTCCTCTGTAGGAGCAGTACAGGCTTTTGGCCTCTGA
GCTGTCTTTCCAGCACTATATCATAAAGCTTTATCACTTCTTCCATTATTTCTTGCTCAGTTCACATGGT
CAAGAAGATTGTCATTTTGTAAATATAAACCCATATCCCATCTGGAGGAGAAACTACACATTTAGTGAGC
AGCTACTTTATGATTGCATGTATGCTACACACTTCTCCCTGTAAGATTCCCACAGTTTAAGAGGGAAATT
CTATCCCTACTTGGAGACTTGGAGAACCTAAGAATTTTTCTCATAGTTGGTGTCTACAGTAGAGTTGGAT
CCTAGGCTGCCTAGCTCCGTGTTCCTGCTCTAGTAGCCATGATGTTGGAGAGCCTTTTCTTTGCCATGGA
GTAGGTAACCAGAAATTCTGGGTGAAAAAACAAAAAACAAAAAACAAAAAACAAAAAACAAAAAACAAAA
AACAAAAACAAAAACAAAAAACAAACAAAAACTAACCCTCACTGTGGGGCTGGGGATGTAGCACAGTGTG
GAGAACCTGCCTGTTGTGTATAGGGCAGGGCCATTGTTGCTCTTTTGTCCTTTCCATGACTCAAACCCTC
CTTGCTGCTATATTCTCTTATCAGCAGAAGGAAGTGGAAATGCAAGAACTCTTGCCTTGGTTTGGGAAGG
ACACAGCACAAGGAGACTCTGACTGCAGGCTCTGGGCACAAAACAACTTCCTCTACAGCTGAATTTATTA
TGTTCATAGTTGAATGGAAAAGACAGGGGAACCAGTTGTTTAATACATTCCATGTGGCAAAGACTTTCAT
TTCAGAATCTTTATTAAAACATGAAGTAGTGGGGCTGGAGACATGGCTCACGGTTAAGTGTGTTTGCAGC
TCTTGCATAGGACCCAGGGTATAGTTTTTAGTACCCACAGAGAGCAATTTACAGCCACCTATAGCTCCAG
GGTCTCAGACACTCTTCTGGTCTCTTGCAGTACCTATAAATATGTGTGCACATATAGAAAAGCACAGACA
AAAAATATATGTGTGTGTGTGTGTGTGTGTGTCTGCATATAGGTATATGCACATGACTGTAGGTGCCTGA
GGAAGCTAGAGATGTTGGATCCCGTGGAGCTAGATGGTTGTTATATCATGGTTACAGATGGTTGTAAGCT
GTCTAATATGGGTTCTGGGTCCTCTAAAAAAGGAGCAATTGCTCTTAACCATGGAACTATCTCTCCAGTC
ATATATATATGCCTAGTATTTTAGACCTGACTGACTTTGAAGAGACTACTCACCCAGTTTCATGAAGCTG
CTAAGGACTATGGAGGGCAGAGCTCTACTGCCTGTAACATGTCATCTGAGCAAGTCACCAATCCACCCCT
AGACTCAATTTCTTCCTCGGCAATGAGGCTGGCACTATTACTCCACAGGTAGATGCAAGGTAAATTGTTC
AGTAGAACCTGTTATGTAGTTCTGAACTGAGAAGACTTAAGGATTAACTGTCCCTAAGAACCAGGAAACG
ATCCTGACAGACCCACCCGCTGCCCATACCTCTCAGTCTGTGCTGCAGGAAGAGGAATACAAGGCCTACA
GAGACCTGCAGGAGGATCGTAGGCACAAGTGCGATGAGAGTCAGCACACCGGGGTTGACCCAATAGAAGG
GATCTGAAAGGCAGAAGGAACACGTCACCCAGACTGCTTCCTAACACCCTGTAAAGAGCTTGTGCTGCAG
TAGGTTGGGTTGAATAAGGGAACCAACATCAAGATTTTAAAAATACTGACACACCCAGGCATGGTCTACA
TACATGACTCCCAGCATTCTGGAGTCTAAAGCAGGAGGATTGCTGCAACTCACTGGACAGCCTGCAAGAC
ATGTCTCAATAAAGAAGGAGGGTGACATAAAGTGAAAATGTTGGTAAAGTAAACTTGTTTTTAAAAGAGA
TGATGTGGCCATTGTTTTTTGTTTGTTAGTTAGTTTGTTTGTTTTGTTTTGTTTTAAACAGGGCAAGTCT
GTCCTGAACTCTTTGTCCTCTAGTTTCTACCTTCCAAATGCTGGGAATTCAGGCCTGAGCTACAACTCCC
CAAATTTTATTCAGTGTTTTCAAAGGAACTCCAACCAATCTTTGTGTCTGTGTCTATGTCTGTGCCTGTG
CCTGTGCCTGTGCCTGTGTCTGTCTGTCTGTCTGTCTGTCTCTCTCTCTCAAGCTAATTAGAGGAATTTG
GAATGTGGACACCAACTCAAAGGAAAGCACTCTCCCCTGAGGCACAGTTTTCATTGTGTGTTCTGCCCCA
CTCCCACCACCTTTCTTATTTGTAATTTGTTGGGTCTCAATGAGTGTACCGGAGTTGGCAGATGAGTTGG
GAATTTGCTAATCAAGAAGAGAGAAAAAAAAAATCTGTATGCTAAAGTTCTGACCTTCCACTTTTTGTGT
GAGTAAAAATTCTCCAGGAAAAAAAAAAAAAAAACCCAGCTGTCTGAGGAACATTCTGTGGCACACAGCT
ATTTTCATGTCCCTGCAAGCTGTCTCTAGAAATAGAGCTTTGTTACTGGGCATACAATGCATCTTCTGGT
CTCAGCCTGACAACAGTCACCACCACCTCAGATACAGAAATGATGGATTGTCTGATGTTCACACTGCAGG
TGCTGAGGAGGAAGGGAAAAGATCAGAGGCCCAGCACTCACAACACTATTGTTCTTCAATTGCATCGCAA
TTAACTTTCTATACGCTCCTTCTGTCTATTTTCCTATCCATGGTTTAACGACTCAGAGGCAGGACAAATA
ATGAATAACTCCAAAACCAGCCACCACACAAAGCATACTGAAAATAAAGTTATAAAGACAAAGAGCAGTG
TCATCGAAACTACAGGTCTCCTCCACTACTGTGTATGTGCTTAATTTTTACTTAGGTGTATATTTGTGTG
GGGGGTATTGGCCTTTGGAAGCCAGAGAAGGCATCGGATCCCCCAGAACTGGAGTTATGTGGGTACTGGA
ACCAAACTCTGGACGCCTGCAAGAGCAACAAAAGCTCTTAAGCACTGAGCCATCTCTGCAACCTCTTGGT
TTTATTTTGTTTCGTTTTAGACGGTCTTTTATATTCTAGGTTAGTGTCTGACTGACTTCTCACCCTCTTG
GCTTTAACTTCTAAGTGCTATGATTACGGGCTTCAGGTTCTAAGATCAGTTTATGCAGTGCTGGGGACTG
AACCCGTGTTTACTTCCATTCTAGGTAAGAACTCTACCAAATGAATTATCCCTGCCATATATTACATACA
CACACACACACATTATATTCCTGTCATACATATAATCCACACACATATATGCATATATATTGAATACACA
CACACACACACACACACACACACACACACACACACACACACATATATCCACACTCAGACACAGGGATATG
TTTTTGTTCCCGATACTCTATAGCTAGCTTATGTAACTCGACAAGCTCTCATGGGAAGCTATCTGGTATG
TCTCTAAAGCAATCATTTTAAGCTGAGCATAGTGACTCATGCTTTTAGTGCCAGCACTTCAGAGGCTAAG
GATGGAGGATTGCCCAAGTTATATATATATAAAAAGTTAGTTGTGCCAGGCGGTGGTGGCGCACACCTTT
AATCCCAGCACTTGGGAGGCAGAGGCAGGCAGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAAAGTGAG
TTCCAGGACAGCCAGGGCTATACAGAGAAACCCTGTCTCGAAAAAACGAAAAACCAAAACCAAACCAAAA
CAAAACAAAACAAAAAGCTAGTTGTGGCAACACATGCATTTAATCCCAGCTCCCAGCTCTTTAGGAGGCA
GAGACAGGAAGACCATTGTGAGTCTGAGGCTAACCTGGTCTATATAATGAGTTCCAGGCCAGCCAGGTCT
ACATGTTAAAAAGCCATCACTTAAAAAGCCAGATAGTCAAAAAGAAGAGCTACCTGGCCGGGTGTGGTGG
CGCACGCCTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGAGGATTTCTGAGTTTGAGGCCAGCCTGGTC
TACAGAGTGAGTTCCAGGACAGCCAGGGCTACACAGAGAAACCCTGTCTCGAAAAACCAAAAAAAAAAAA
ATAAAAAAATTAAAAAAAAAACAAAAACAAAAACAAAATAAAATAAAAACCGAAGTGCAAGAGCATTTGT
CTAGCTTAGATATCATCTTTTTATCTAATGTCACCTTCTTAGCCATGAAAAGGGACTTTGATTCCAGTTT
CTTTCCCAATTCAAATAACAAAATAACCAACAGCCATAACATAGGCATCCCTGTTTACTGACGTGTCTGT
TCCTTTGGATTTGATCTCAGAAGTGACAAGTTTGGGTAGAAAAACCTTATCTCAGCCGAAGGATGAAGGG
AGGTCAACTATCCTACAGGTCATTTGACCTTGGAGGACTCACCTTCCACTTTCAACTCCATTGCTGCCTC
TTCTTGGTAAGAGTGGTCTCTGAAGAAGCAGGTGTAGCCTCCTTCATCTGAGAATCTCACGTTCTGAATC
CTAAGGGTAACCTTTCCCTCACTGATAGTCTCTTTCAGAAGCTCTGTGCGTCCCCGGTATTCAGGTGCTT
GCTCTGCATCTTGGTCCTTGCCATTTCGGTAGAGGTGAACCACTCTTGAGAAGGGAGAACGGTACCAACC
CACCTCCATGCCCGTGGCATTTTTCCCAGGAGAGATGCGGCACGGCAGCTCTGCTTCATCCCCAACTAAA
GCCCGGATGGGATACCCTGGTCCTATCACTCTGAATTGTCCTGTCCAAGACACAAGAGTGGGAAAAAATA
ACAACAACAAGTATCAGATGTGACAAATTCATCCATCATAAGAAGGCTGCTTCAAAAAGGGTGAGAGGGC
CGGGCGGTGGTGGCGCACAACTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGCGGACTTCTGAGTTCGA
GGCCAGCCTGGTCTACAAAATGAGTTCCAGGACAGCCAGGGCTATTCAGAGAAACCCTTTCCCCCCTCCC
CCCCCCAAAAAGGGTGAGGAAGGAAACATTTTTCATTTTTATTTTATTTTTGAGACAGGATCTCACTGTG
TAGCCCTGGCTGGGCTAGAACTCACAGAGATCTGCCTGCCTTTGCCTCCCAAGTGCTAGGATCAAAGCTG
TATACCACCACACTCAGTGGTTTGTTTTATTTTAAAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTATCAGTACACACATGAGTGCAGGTGACTTCAGAGGCCAGAGGCATTTGTCACCTCCCCCCCCCCCCCC
ATCTCCAGTCCTTTGTAAGTGAAGTATATACTCTTTACCACGGAGTCATCTCTTGAGCCCCTATTTATTA
ATTTTGAGAAAGGATCTTGCTCTGTAGTGCAGATTGGTCTTGCACTCATAGCAATCCTCCTGTCTCGCCT
TTTTAAGTGCTGGAATTATGAGCATGTGCCACTGTGCTTAGCTTAGGACACTCAATTTTTTTGGTAAAGG
TTTTGCCTCTGTATCAGAGTGGGTGACTCTATGTCACCTTTGTGCAGCTACTCTTGGAACCCATAAGAGG
CTGTGAGATCCCTTGGAGTTGGGGTTACAGGTAGCTGTGAGCTACCCCATAAATGATGGTACTGAGACCC
CTACCTTGGATCTTCTGCAAGAGCAGCGAGCATACTTAACTGCTGAATCATCTCTTCAATACCTCTCCTC
ATTATTTGATTTTTTTTTTTTTTAAGACATGCTTATAGTTCAAGCAGGCCTTAATCTTCCATGTAGCTGA
GACTGACTTGAATTTCTGGTCCTTCTGCTTCCATCCCACAAATGCTACAATTATAAGTAAGGGTTCACCA
CCAGGCCAGGTTTGGGAATATCACATGGAATTCATGAACCCTCAGTAGGGCTTTTTTTTTTTTTTTTTAC
TTTAAGCTAATATGAAGTAAGCAGTCTCTAGGAAAAGATATGTTCTGAGCCGGGCGTGGTGGAGCACGCC
TTTAATCCCAGCACTTGGGAGGCAGAGGCAGGCAGATTTCTGAGTTCAAGGCCAGCCTGGTCTACAAAGT
GAGTCCCAGGACAGCCAGGGCTATAAAGAAAAATCCTGTCTCGAAAAACCAAAAAAAAAAAAAAAAAAAA
AAGATATGTTCTGAATGTCTAGGACAGAATGCTCCACCATGAAATCATCTGACAATGGCTTCCACTTTTC
TACCAGCTATGTTCATCTCTGACTCCTCAGCTCAGATGCTTGCCTCCTTGTCATGTGGCCCACTACTTCT
AAGTGCTTCCCAGCGCTCTAGGTTGTTGGGAGTCACCCCATGGATGTGGGTGCCGGTAATCAAACTCCAG
TTTCCCATAAGAGAAGTAATACTCTTTACCACAAAGCCATCTCTCTAACCCCTATGTATTAATTCTCTTC
TTTTCATTTGTATCTTCAGCCTTATGCTAGCTCTGGAAACTTCTCTGGACATCTCCCCAGTGAGAATCAG
CTACTAGCAAACTGGGCTCTTCCTTATACCAGGATGCCCACAGAGGATGCCTGGACTAGGGCGGTTTCTT
TATTTCTTCTTTTAGTTGGACAACAGGCTCCTGTATCTCTGCCTTATTCTGCAGAGCAAGTTCTCAAACA
TAACTCGATGCTATAACTCAACTTGTTTTTGTTTTTGTTTTTAAATATATTATTTTATTTGTGTTGTTTC
ATTTTAGCATTCAGGCTTAGAGACAAGCACATTTGCCCACTGAGCCACCTCACTGACCCTCAACAAACAT
TTATTGAGATCTGCTACAAACAGGCATTGCCTTAATGTGCAAAGTACAAAAATACTCTCACTTAACTCTG
ACGGTAACTCCAAGAAGTTAGTGTCCTCTTTTGAACGATGAAAAAAGGAAACGAAACTAGGGCTACAGAT
AGAGCTTAGTTGTGAATTGTGAACTTAGCTTGCACCAGGCCCTGAGTTTAATTCCCAGTACCATATGAAT
AGGGAAAGGTTTGGGTTTACCCGCCCCCCCCCCCCAAGAAGTCAGGAAGGCCTTTAAGGAGAGAGACTAT
GCCAACAGACCCAAGCATAAACAGGAAGTTTGTATAGCCATTTGAGGATGATTAAAAGAGGTTAGCCAAG
GACACTCCCTTTCTGCTCCTAGGTCTCTGCAGGGGTGGAATGAGCATGCTTACCTGCATAGCTGCATGAC
AACTGGAGGAGAAGGAGGAGGAGAAGGGAGAGGAAGCAGCTGGGCCAAGAGAAGCTCCACAAACAGGCCA
TCTTTATGGTTACCGGGGACAGAGTCCCTAACAGCAGGGTCAGGCCAAGCTGAGGTCCTCCGGCTGCATG
TCCCTTCCTCCAAGAAGCCCGAAGGGAGAATCTGGGAGGGCACTACTGCCCAAGCCCAACCTCCATGTAA
GCATTACCACAGCTGTGCCCTGAGGAATGGCCCCACGTCACCCTTGCCAGATATTTGTA
  • Protein Sequence : Show Sequence 
    >NP_034944.2 myelin-oligodendrocyte glycoprotein precursor [Mus musculus]
MACLWSFSWPSCFLSLLLLLLLQLSCSYAGQFRVIGPGYPIRALVGDEAELPCRISPGKNATGMEVGWYR
SPFSRVVHLYRNGKDQDAEQAPEYRGRTELLKETISEGKVTLRIQNVRFSDEGGYTCFFRDHSYQEEAAM
ELKVEDPFYWVNPGVLTLIALVPTILLQVSVGLVFLFLQHRLRGKLRAEVENLHRTFDPHFLRVPCWKIT
LFVIVPVLGPLVALIICYNWLHRRLAGQFLEELRNPF
  • Molecule Role : Protective antigen
3. Mog
  • Gene Name : Mog
  • Sequence Strain (Species/Organism) : Rattus norvegicus
  • NCBI Gene ID : 24558
  • NCBI Protein GI : 158262022
  • Genbank Accession : BX883052
  • Protein Accession : NP_073159
  • Taxonomy ID : 10116
  • Chromosome No : 20
  • Gene Starting Position : 4044676
  • Gene Ending Position : 4054908
  • Gene Strand (Orientation) : +
  • Protein Name : myelin oligodendrocyte glycoprotein
  • Protein pI : 8.13
  • Protein Weight : 25744.92
  • Protein Length : 245
  • DNA Sequence : Show Sequence 
    >gi|389675109:4044676-4054908 Rattus norvegicus strain BN/SsNHsdMCW chromosome 20, Rnor_5.0
AGGCTTCTTGGGGTAAGGGACATGCAGCCAGAGGGCCTTAGCTTGGCCTGATCCTGCTGTCAGGGACCCT
GTCCCCAGTAACCATAAAGATGGCCGGTGTGTGGAGCCTTTCTCTGCCCAGCTGCCTCCTGTCCCTGCTC
CTCCTCCTCCAGTTGTCATGCAGCTACGCAGGTAAGCATGCTCCAGCCCTGCAGAAACCCAAGAGCAGAA
AGGGAGTACCCTTGGCTAACCTCCTCTATTATCCTCAAATGGCTACACGAACTTCCTGTCTACACTTGGG
TCTGCTGGCACGGCTTCTCTCCTTAGAGACCTTCCTGACTTCTTGGAGAATAAAATCCAAACCTTTCCTC
ATTCAAATGGTGATGGGAACCAAACTCAGGGCCTGGTGCAAGCTGAGTTCTAAGCTCTATCTATAGCACT
AACTTCTTGGAGTTACTGTCAGAGTTAAGTGAGAGTGTTTTGGACTTTGCACATTAAGGCCATGCCTGTT
TGTAGTAAATCTCAGTAAACGTTTGTTGAGGGTTGGTGAGATGGCTCAGTGGGCAAACATGCTTGCCTCT
TAGACTGGATGCTAACATGAAACAACGCAAATATGAAAAAAATAGAAACACATTGAGTTATAGCACCGTG
TTATGTTTGAGAACTTGCTCTGCAGAATAAGGCAGTGATACGTTTTTATCCAGGAGGCTGTTCTCCAACG
AGGAGAAGAAATAAACACTAGACAGAGTTCTACCTCAGGGAGCCATGTGATTGACAGAGCCCTGGCCCAG
GCACCTTCTGTGGACACCCTAGTACAAGGAAGAACCCAGCTTGCTTGCCAGTAGCCTAATCTCACTAGGG
AGATGTTCAGAGAAGGTTTCAGAGCTGGGATGAGGTTGAAGATACAAAATGAAAAGAGACTTAATAAATA
GGGGTTAGAGAGATGGCTCTGTGGTAAAGAGTATTCCTTCTCGTACAGGAGACTGGTTTTTTGGTTACCA
GTACCCATATCCACGGGGTGGCTCACAACAACCTGTTACTATCTGGGGAGGCAGCTATCCCCAGAGTGTG
TGACTTCCTCAGTGGAGAATGAGATGTGAGGAGAGAGGGCTGGGAAGCATTTAGAAGCCACATGACAAGG
AGGAGGCAAGCATCTGAGCTGAAGGGTCAGAGATGAACGTAGCTGATAGACAAGTGGAAGTCACTGTCCA
GAGGGTTTCATGTTAGAGCCTTCTGTCCTAGACATTCAGAACATATCTTTAAGTAGAGACTGCAAATTTC
GTATTTGTTTAAAGTTAAAGAAAAAAAAAAAAAAAGCCCTACCGAGGCTCGTGAATTCCGTTTAAAATTC
CTAAACCTGGCATGGAGGTGAGCCCTTGTAATTGTAGCATTTGTGGGATGGAAGGAAAAGGACCAAGAAT
TCAAGTCGTTCTCAGCTACGTGGAAGTTTAAGGCCTGCTTGAGCCATGAGCGCCGTGTCTTAAAAACTGA
AGAGTTGATTCAACAGTTAAGTACGCTTGCTGCTCTTGCAGGGGATCCAAGGTAAGGTTCCCAGCACCAT
CCTCTATGGGGTAGCTCGAAGCTACCTGTAACCCCAGCTCCAGGGGACCTAACAGCTTTTTACAGATTCT
AAGAGTAGTCACGCAAAGGTGGCATACAGTCACCCACACACACACACACAGACACACACACACACATATA
CACACACACACTTTAAAATAAAACAAATCACTGGATATGGTGGTATACAGCTCTGAGAGGCAAGGGCAGG
CAGATCCCTGTGAGTTCCAGGCTAGCCAAGGCTACGTAGTGTCTCAAAAATAAATAGAATAAAAATGAAA
AAATCATGTTTCCTTCCCCTCACTCTTTTTGGAGCGGCTTTCCTATGATGGATGAATTTGTCATATCTGA
TTCTCGCTTTTTTTTTTTCTCCCTCCCCTTTGGTGTCTTGGACAGGACAGTTCAGAGTGATAGGGCCAGG
GCATCCCATCCGGGCTTTAGTTGGGGATGAAGCAGAACTGCCGTGCCGTATATCTCCTGGGAAGAATGCC
ACGGGCATGGAGGTGGGGTGGTACCGTTCTCCCTTTTCAAGAGTGGTTCATCTGTACCGAAATGGCAAGG
ACCAAGACGCAGAGCAAGCGCCTGAATACCGGGGACGCACAGAGCTTCTGAAAGAGTCTATCGGCGAGGG
AAAGGTTGCCCTCAGGATCCAGAACGTGAGGTTCTCGGATGAAGGAGGCTACACATGCTTCTTCAGAGAC
CACTCCTACCAAGAAGAAGCCGCCGTGGAGTTGAAAGTAGAAGGTGAGTCCTCCGAAGCCATACGCAGTA
TGGACTGTGGGGTAGTTGACCTCCCTTCATCCTCCAATCACCCAGCTGAGGTCTTTCTACCCAAAGACCT
CACTTCCGAGATCGATCCCAAGGGGACAGACGCAACAGTAAACAGGGCTCTTATGCTGTGGCTGTTGGTT
ATCTCGTTATTTGAATCAGGAAAGAAAACTAGAGTCGAAGCCCGTTCTCACGGCTAAGAACGTGACTTTT
TGGTATCTAAGGTAGACAAATGCTCCTGCACTTCAGTTTCTGTTTCTGTTTGGTTTTGAAATGATGCCTT
TTCAACATGTAGCCGCTGGCTGGCCTAGAACTCACCCTATAGACCAGGTTAGTCTCAGACTCAAAATGGT
TCTCCCGTCTCTGCCTCCTAAGTGCTGGGAGCTGAGATTAAAGGCATGTGATACATACATACATAAATAT
ATACATACATACATATATATATATTGGGCAATCCTCCAGCCTCGGTCTCCTAAGTGCTGGGACTAAAAGC
ATGAGTCACCAGCTCAGCTTAAAATGATCGCTTTAGAAACATACCAGATAGCTTGGGTGCTTCCCTCAAG
AGCTTGTTGAGTAACATAAGCAAGCCATAGAATATAGGGAACAAAAACATATCCCTGTGTTTGAGTGTAT
AATTACACACACACACACACACACACACACAGTCATATATATATATATATGCACACTCAATATGTATATA
TGCATATACGTGTGTGGATTCTATGGCAGGGATATAGTGTGTGCGTGTGCGTGTGCGTGTGCGTGTGCGC
GTGCGCGTGCGCGTGCGCGTGCGCGTGCGTGTGCACGTGCGTGTGCGTGTGCGTGTGCGTGTGCACATGC
GTGTGCGTGTGCACATGCGTGTGCGTGTGCGTGTGCGTGTGCACATGCGTGTGCGTGTGCGTGCGTGTAA
TATATGGCAGGGCTAATTCAGTTGGTAGAGTTCTTACCTAGAATGGAAGTAACCATGGGTTCAGTTCCCA
CCACTGCCTAAACTGATCTTAGAACCTGAAGCCTGTAACCGCGGCTCTTAGAAGTTGAAGTCAAGAGGAT
GAGAAGTCAGACACTAACCTCCAATATGAAACTGCCTCAAACCAAACCAAACCAAACCAAACCAAACCAA
ACCAAACCAAACAACCAAACCAAGAGGCTGGGAAGATGGCTCAGTGCTTAGTAGCTTTTGCTGCTCTTGC
AGAGAGAGGTTCAGAGTTTGGTTCCAGTACCCACATAACCCCAGCTCTGGGGGATCTGACACCTTTTCTG
GCCTCCAAAGACCAATACCCAACCCCCAAATATAGACCTAAATAAAAATTAAGCACACATACACAGTGGT
GGAGGAGACCCGTAGCTTCAGGACACTGCTTTGGTTTTTAAGATATTTATTTATTTATTAATTATATATA
AGTACACCGTAGCTGTCTTCAGACACATCAGATCTCATTACAGATGGTTGTGAGCCACCAGGTGGTAGCT
GGGAATTGAACTCAGGGCCTCTGGAAGAGCAGTCAGTGCTCTTAACCGCTGAGCCATCTCCCCAGCCCTC
TGCTTTGTTTTTCTAACTTCATTTTTCAGTGTGCTTTGTGTTGTGCGGTGGCCGACTTTTGGAGTTACTC
CTTATTATGTGTCCTGCCTCAGAGTGGTTAAAGCATGGATAAGAAAACAGACAGGGAGCGTTGAAAGTTA
ACCGCGATGTAACTGAAGAACAAAAGTGTTGTGAGCGCCGGGCCTCTGACCCTTTCCCTTCCTCCCCAGC
ACCTGCAGTGTGAGCATCAGACAATCCATCATCTCTGTTATCTGAGGTGGGGGTGACTGTTGCCAGGCTG
AGACCAGAAGATGCATTGTATGCCCAGTAACAAAGCGCTATTTCTAGAGACAGCTTGCAGGGACATGAAA
ATAGCTGTGTGCCACAGAATGTTCTTCAGACAGCTGGTTTTTTTTTTTTTTTTGGTTGGGGAAATTTTAC
TCACACACACAAAAAAAATGTGGAGGGTCAGAACTTTAGCATACAGATTTTTCTCTCTTCCTGATGAACA
AATTCCCAGCTCATCTGCCAACTCCAGCACACTCATTGAGACTCAACAAATTGCAAGTAAGAAAGGTGGG
GGTGGGGGATAATGTGGCAGAACAGGCATTATAAACTGTGCCTTGGGGGAGAATGCAGTGTTTTCCTTCA
AGTTGGTTTCCACATTCCAAATTCCTCTTGTCAGCTCCCGGTTTGCTTGCCTGACACACACACACATACA
CACACACACACACAGACACAGAGAGACAGAGACAGAGACGGAGAGACAGAGACAGAGAGAGTGGTTGGAG
TTCCTTTCAAAACATTGAATAAAATTTGGGGAGTTGTAGCCCAGGCCTAAATACCCAGCATTTGGGACGT
AGAGGCTGGAGGACAAAGAGTTCAAGGACAGATTTGCCCTGTTTAAAACGAAACAAACAAAAAACAATGG
CCACATTATCTCTTTTAGAAACAAACATACTTTACCAGCATTTCCATTCTATGTTACCTCCTACCCCTCA
CCCCCCAATTTTATTGAGACAGGTCTTGCAGGCTGGCCTGTGAGTTGCAGCAATCCTCCTGCCTTAGACT
CCAGAATGCTGGGATTAGGGGGTATGCGGCACCAGGCCTGGGTGTGTCAGTATTTTTAAAATCTTGATGT
TGGTTCCTTTATTCAACCCAACCTCCTGTAGCACAGGCTCTGTACAGGGTGTTGAGGAATTGGTCTGCGT
GATGTGTTCCTTCTGCCTTTCAGATCCCTTCTACTGGATCAACCCTGGCGTGCTGGCTCTCATTGCCCTT
GTGCCTATGCTGCTCCTGCAGGTCTCTGTAGGCCTTGTATTCCTCTTCCTGCAGCACAGACTGAGAGGTA
TGGGTCTGTCAGGATCCTTTCCTGACTCCTAGGGACAGTTAATCCTTAAGTCTTCTCAGATCTGAAGTAC
ATAACAGGTTCTGCTGAACAATCTACCTTGCACCTACTTGTGAAGTAAGACTGACAGCCTCGTTGCTGAG
GAAGAAATTGTATCGAGGGGTGGTTCAGTGACCTGCTCAGATGACATGTTACAGGCAGTAGAACTCTGCC
CTTCTAGTCTTTAGCAGCCTCATGAAACTGGGCGAGTAGACAGTCAGATGTAAAATACTACGCATTTGAA
ATAAATAAACCCTAAGGAAGGGCTGGAGAGATAGCTCCATGGTTAAGAGCAATTGTTCCTCTTCTAGAGG
ACCCTGAACCCACATCAGGGAGCGTACAGCCATCTGTAACCATGATGTAATAGCCATCTAGCTCCATGGG
ATCCAACATTTCTGGCTTCCTCAGGCACCTGCAGTCATGTGCATATACCTACATCCAGACACACAATTAA
AAATTAAATCTTACGATTTTTTAAACTTTCGAATTTATTTTTGTGCATGCTTGTCTATGTGTGCCCATGT
GTTTATAGGTGCTGTAAGAAGCCGGGAGAGTGTCAGAGACCATGGAACTGGAACTATAGGTGGTCGTTAA
GGTGCTCAGTTCCAGGCTCTTGTGGTCTTCCATTATTTCATTCAGACAACACCCACAGACAGAGGCTGAA
TTCTTGGTTTTAAATCTAGAGTTCTTCCTACTCTCCTAAGACACTCCCAGGCCATCAAACAAATCCCCCA
CACAAAGGTCAATGGTGCTGGGTGTAGAAGGGTCCTCATTTTGTCAGATCAAGAACTAAAAAACCTGCCC
TTTTCTATTTTAGGAAAACTCCGTGCAGAAGTCGGTGAGTTCCAGGCGCCCTCCCTCCCCGACTCATCTT
ATCTTTTAGCTTAACCAAAATGTCCTTCTCTTCAGACCATTTCTGCCTCTCCCCCAAAGCTCCGTGCTCT
CTCCAGTTGGGAACTTTAATATTTAAAACTACAGGTGGCTCAAATTTAGAAGTTGTTTGACCTGAGTTCG
GTTTACTTTTTTGTCAGGGCTAGAACCAGCCTTGGGGGATTTAGATAGGTCCAGGGAAGGAACTCCCTCC
CTCTCAGCTCCTTACTGAACCTATTCTTATTTGTCCTTTCAGAGAATCTCCATCGGACTTTTGGTAAGTT
CAGACATATCCCAACCTTCCCAAGTCACTGTGGGATTTCACTAGTGGCCTGGGGGATGCGGGGGTGGGGT
GGGGGGTGGAGACTAGGAACAGTGGCTTTTTGTAAGGCTCCCCTATATCTCTTTTCTTTGAATTCAAGAT
CTACAGGAATGTAGCAAACATTTATGTACCATATTCCAATGTCAGGCCCTGCGTTGAATTTTACAAATTG
TAAACTTATTATATACATAACTATCTATATCTATCTATATATTATTTTATATATATATATATATATATAT
ATATATATATATATATATAAAATCTTTCAAATTATAAAAAAGTGGTTAAAGAAATCCTTTGCACATAAAA
TTGTTTTCCCGATGGGAAAATGAAATATACTTCAATAAGACACCGTCACTGGGCCTAAAGACATGGCTCA
GTGGTTAAGAGCACCTGTTGCTCCCCTAGAAGACATAAGTTTTTTTCTCCTGACCCCGCAGCAGACAGCT
GTACGCACAAGGCGTACATATGTAAGAAAAAATAATTTTTTTTTTTTTGAGATATGGTCTTGCAACGTAG
CCCTGGCTAACCTGGAATTCGCCATGAACGATAGGCTGGCCTTGAACGCACAGAGCTCCACCTGCCTCTG
CTTCCCCAGTTTTGGGATTAAAGACATGTGCCACCATATCCAGAAAATTACGTTTAAAAAGTCATCTGCT
ATACTTTTAGGGCAGAATTGGTCTTCAGGAGTAGAGTCCAAGCACACGATTCATCAGGGAAGGTTTCTCT
GAGGAGAAAGTAAAGCCTCACTGGTTAACTTTTTTTGAATCAGGGTTTCATATGGCTATGCTGTGTGTGT
CATGATAGCCTTGGGCTCTGATCCTCCTGCCTTCAACTCCCAAGTGCTGATAATGTGCACATTCAACCAT
GCATGCCCCAACTAGAATATGAATTCCCCAGGAATCAACTTTGCCTTTTATTCACTTCAGATTGCAGAGC
TCCTAAGGCCACCACCAGCAATACCCAAATGCTTGTGGAATGGATTCCATACAGCTAAAAAGCAACATTA
GGCAGAGAACGGGAAATCTGTGCTCTGATCAACCTTCCTAAACACAAACAGCCTTTCCTTCTGCAGTCAT
ATGTAATCCTGTTCAGCTCTCCTGGTACTTGGCACACTCAGTAGGTTCCACCGTAGCACTTTAGTGTACG
GATGTCACACATGTAGTCTTTGAACACATTTTATTACCCGTGTGTGGAGGTGGGTGACAGAAAGTGCTCA
CAGAGGTCAGAGGGACAGTAAGGAGGAGTTGATTCTCTCCTTCCCTCGTGTGGGTCTGGGGATCAAACTC
AAGTTTAACAGCAAGTGCCTTTATCAACTACGCCATCTCCCGGATCCCATCCCATCCCATTTTGTTTTGA
AGTGTCTGTCTCATGTATTTCAGGCTGGACTCAAACTTGCTATGAAGCCAAAGACTGTCTTGAATTTTGA
TCCCCCTGCCTGTACCTCCTATATTCGGGGGTTATAGGTGTGAGCCGTACATGCTGTGCTAGGAATGGAA
CGCAGAGCTCTGTGCAAGCTACAAGAATATAACCCTACAAACCGAGCTGCCTTCCCAGCCCCCAGGAAGG
GGCTAATACCAGTTTTTGACTTTTCATTTTTGCTATTTTTCTCTTCCCTTCGAGACTTGAACTCAGTAGT
GTGTCTGAAGACAAATGCAGCCAGCGCACTCATATAAATAATAAATAAATCTTTAATAAAAAGGAAACAT
TAGTGAAAGCAGGGTTGACAACTTGTAATCCCAGCACCTGGAAGGCGGAGGCAGGAGGACTTCTCAAGTT
CAAGGCCAGCCAGGGATTGTACAAGCAAGAACCCCTCTTCAAAAAACACGCGCACACACACAAATGCTAG
AAGTGGGGGCGAGGGAGGGACAGCGTGTGGCTGAAGATCAACAAAGCATGAAAGGGTCACACCACCCATT
GTCTTCTACGATAAATCGGTTAAAAAGATACAGCTAAATTCAATCAGAAGCTAAAGGAAGTAAAAGCAAG
GCGCACAATGTACCTCATCTACATTCATGGACTCTACAGCTTGTCCTGGCTTTGGAGGCTTCAAGTGGGT
GTGGCATGAGCGGCTGTGGCATAGAGGGAAACACTCTGTTCTGCTTTACCATTCAGATCCTCACTTCCTG
AGAGTGCCCTGCTGGAAGATAACACTGTTTGTTATTGTCCCTGTTCTTGGACCCCTGGTTGCTTTGATCA
TCTGCTACAACTGGCTGCACCGAAGACTGGCAGGTGCAATGTCTGGGCAGCAAACAGGACCACTGTGGGG
CGGGGGGGGGGGGAGGGGGGGGAGCTCAGGCAGACCAGAACGGGAAAAGAGTGGAACCAAGGTTCTAGAT
CCCAGGGCTGAGAATCTTTTTGCTCTCTCTACTCTCACCATCAGAATCCTCAGGAAAACTGAGGACCACT
TACTGAGATGCACAGGCCCCTTAATGGAAAAGAAGGGTTGTCTGAGGAGGTGGGGGGGAGGCTCCCACTG
GTCACCCATCGACTCATTTCTCTTTGTTTACAGGACAGTTTCTTGAAGAGCTAAGTAAGTTCTCCCTAAC
GCCCCTCTCCATTCTTGAGACATCTCATTACGCAGCCCTAGAACTCACTATGTAAACCAGACTGGTCTGG
AAACTATGGCAATCCTCTTCTCAGCTCCAAAGTGCTAAGGTCATAAGCAAATACCACCGAACCCAAGTGT
TTTTTTCCTTCTAAACTGATCAAAAATCCAGCAGAGGAACATGGTCACTGGGGGACCATAATCCCAGGGA
GGGCTGGAATGATTCCTTCTGTGATGGAAAAGGGAAGGGAATTAACTGTTAAGAGACACCACTTTCAGCG
CCAGAGAAGCTGCTGAGCCACTCCACTCTTACCTGTTGACTTGATAGCCTTTAATGCCCCACAGCCAGAA
TCCCATTTCTGTAGCCTCCTTTGACATTCTCCCTAATAGTTAGCCTGACTGAACCTCACCTCCCTTCGAT
AACATGACCCCCGTGAGCTTTCTACCTCCTAGGTTCGATGACTTCAAGAACCCACTGGCAGATTTTTTAA
GTCACTTGTCTTTCTTTCTAGGAAACCCCTTTTGAGTGATGGTGCATCTTCCTGGAGCGAAGGAAAGCCT
GGCAGGTCCTTGGGGATGTCTCTCACTGGCCTCTCTGTTATGGACACATTCCAATCTACATCTACAGAAA
CACTCGGGATCCTGAGTAGAACTTGATTTTCCTCCCACAACTGTCTTTCTTTCCTCAGCTCCTTCCTCTA
AATCTTTTTTGACTCCTGTCTTAGTCTGCCTCTAGAAAACACCCCATGACTAAGGCCAGGGAGTCTATCA
GGAGACACCTATGTACCAGAGTAATACAGGAGTGATTCTGCCAACCAGGACACCCAGCGCTTCAACATTA
CGATCTACAGAACATCAGCTCTGCAAATGGTGGATATTTCTTCCAGAGCCACAGTCTTGACTGGGAAGAA
TATCAGTGGGGAGAGTAAGGGGGTGAGGGACAGAAGAACCCACAACATGAGGGAAAGCTAAATGAGCCAG
GGTATGAATATGGGAGCCTGAACCAAAACCTGGAGATTAAAAAAAAAAGTCAAAAGAATACTGACTGGAT
CAGAGCAACACCATCTTGCTTTGGCAGCCTGGTGGGAGGACCTTGAGAAGCAAGGGTCGAGAACTGGGTC
TGTTCTCTCATTTTTCTCCTATCTTATTTGAGTACCCACTGTTTGGTTTTTTTTTTTTTTTTCTTCTTCG
TTTTTTCAACAATTACTACTTGGTGGTGTATCAGACACAAACAAGCTAGGTGCTAATTAATAATAATACA
AGTTTCTTTGTGC
  • Protein Sequence : Show Sequence 
    >gi|158262022|ref|NP_073159.2| myelin-oligodendrocyte glycoprotein precursor [Rattus norvegicus]
MAGVWSLSLPSCLLSLLLLLQLSCSYAGQFRVIGPGHPIRALVGDEAELPCRISPGKNATGMEVGWYRSP
FSRVVHLYRNGKDQDAEQAPEYRGRTELLKESIGEGKVALRIQNVRFSDEGGYTCFFRDHSYQEEAAVEL
KVEDPFYWINPGVLALIALVPMLLLQVSVGLVFLFLQHRLRGKLRAEVENLHRTFDPHFLRVPCWKITLF
VIVPVLGPLVALIICYNWLHRRLAGQFLEELRNPF
  • Molecule Role : Other
III. Vaccine Information
1. EAE DNA vaccine pZZ/MBP68–85 encoding MBP
a. Vaccine Ontology ID:
VO_0004401
b. Type:
DNA vaccine
c. Status:
Research
d. Host Species as Laboratory Animal Model:
Rat
e. Gene Engineering of MBP
  • Type: DNA vaccine construction
  • Description: This DNA vaccine expressed an autoantigenic peptide, myelin basic protein peptide 68-85, from guinea pigs (Lobell et al., 1999).
  • Detailed Gene Information: Click here.
f. Immunization Route
Intramuscular injection (i.m.)
g. Rat Response
  • Vaccine Immune Response Type: VO_0000286
  • Efficacy: The pZZ/MBP68–85-treated rats were protected from EAE. The control plasmid pZZ, which does not encode MBP68–85, failed to protect from EAE (Lobell et al., 1999)
IV. References
1. Bourquin et al., 2000: Bourquin C, Iglesias A, Berger T, Wekerle H, Linington C. Myelin oligodendrocyte glycoprotein-DNA vaccination induces antibody-mediated autoaggression in experimental autoimmune encephalomyelitis. European journal of immunology. 2000; 30(12); 3663-3671. [PubMed: 11169409].
2. Lobell et al., 1999: Lobell A, Weissert R, Eltayeb S, Svanholm C, Olsson T, Wigzell H. Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). 1999; 163(9); 4754-4762. [PubMed: 10528174].
3. Lobell et al., 2003: Lobell A, Weissert R, Eltayeb S, de Graaf KL, Wefer J, Storch MK, Lassmann H, Wigzell H, Olsson T. Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis involves a T1-biased immune response. Journal of immunology (Baltimore, Md. : 1950). 2003; 170(4); 1806-1813. [PubMed: 12574345].
4. Ramshaw et al., 1997: Ramshaw IA, Fordham SA, Bernard CC, Maguire D, Cowden WB, Willenborg DO. DNA vaccines for the treatment of autoimmune disease. Immunology and cell biology. 1997; 75(4); 409-413. [PubMed: 9315486].
5. Ruiz et al., 1999: Ruiz PJ, Garren H, Ruiz IU, Hirschberg DL, Nguyen LV, Karpuj MV, Cooper MT, Mitchell DJ, Fathman CG, Steinman L. Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation. Journal of immunology (Baltimore, Md. : 1950). 1999; 162(6); 3336-3341. [PubMed: 10092787].
6. Selmaj et al., 2000: Selmaj K, Kowal C, Walczak A, Nowicka J, Raine CS. Naked DNA vaccination differentially modulates autoimmune responses in experimental autoimmune encephalomyelitis. Journal of neuroimmunology. 2000; 111(1-2); 34-44. [PubMed: 11063819].
7. Tsunoda et al., 1998: Tsunoda I, Kuang LQ, Tolley ND, Whitton JL, Fujinami RS. Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA. Journal of neuropathology and experimental neurology. 1998; 57(8); 758-767. [PubMed: 9720491].
8. Waisman et al., 1996: Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nature medicine. 1996; 2(8); 899-905. [PubMed: 8705860].
9. Walczak et al., 2004: Walczak A, Szymanska B, Selmaj K. Differential prevention of experimental autoimmune encephalomyelitis with antigen-specific DNA vaccination. Clinical neurology and neurosurgery. 2004; 106(3); 241-245. [PubMed: 15177776].
10. Weissert et al., 2000: Weissert R, Lobell A, de Graaf KL, Eltayeb SY, Andersson R, Olsson T, Wigzell H. Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(4); 1689-1694. [PubMed: 10677519].
11. Wiki: Experimental autoimmune encephalomyelitis: Experimental autoimmune encephalomyelitis [http://en.wikipedia.org/wiki/Experimental_autoimmune_encephalomyelitis]