VIOLIN: Vaccine Investigation and Online Information Network

Feline panleukopenia virus

Table of Contents

General Information
Vaccine Related Pathogen Genes
1. VP2 (Protective antigen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

10786

2. Disease:

Feline Distemper

3. Introduction

Feline panleukopenia, commonly known as feline distemper, is a viral infection affecting cats, caused by feline parvovirus, a close relative of canine parvovirus. It is not related to canine distemper (Wiki: Feline Panleukopenia). Feline panleukopenia virus (FPV) is a non-enveloped virus which is resistant to physical factors and chemical substances. The virus can remain infectious for months outside of a host and is highly contagious (Truyen et al., 2009).

4. Microbial Pathogenesis

The virus primarily attacks the lining of the gastrointestinal tract, causing internal ulceration and, ultimately, total sloughing of the intestinal epithelium. This results in profuse and usually bloody diarrhea, severe dehydration, malnutrition, anemia, and often death. The virus causes a decrease in the cat's white blood cells, thus compromising its immune system. Typically, it also causes a decrease in hematocrit and platelet counts on a complete blood count (Wiki: Feline Panleukopenia).

5. Host Ranges and Animal Models

FPV can infect felids, raccoons, mink and foxes (Truyen et al., 2009).

6. Host Protective Immunity

Antibodies are critical in the immune response to FPV, and can protect kittens from fatal infection. Active immunity is solid and long lasting and can be achieved through the use of either inactivated or modified live virus vaccines (Truyen et al., 2009).

II. Vaccine Related Pathogen Genes

1. VP2

Gene Name : VP2
Sequence Strain (Species/Organism) : Feline panleukopenia virus
NCBI Protein GI : CAA38911
Other Database IDs : CDD:279128
GOA:P24840
InterPro: IPR001403
InterPro: IPR013607
InterPro: IPR016184
PDB: 1C8E
PDB: 1C8F
PDB: 1C8G
PDB: 1FPV
UniProtKB/UniProt: P24840
Taxonomy ID : 10786
Protein Name : VP2
Protein pI : 5.45
Protein Weight : 61215.01
Protein Length : 639
Protein Note : Parvovirus coat protein VP2; pfam00740

Protein Sequence : Show Sequence

>CAA38911.1 VP2 [Feline panleukopenia virus]
MSDGAVQPDGGQPAVRNERATGSGNGSGGGGGGGSGGVGISTGTFNNQTEFKFLENGWVEITANSSRLVH
LNMPESENYKRVVVNNMDKTAVKGNMALDDIHVQIVTPWSLVDANAWGVWFNPGDWQLIVNTMSELHLVS
FEQEIFNVVLKTVSESATQPPTKVYNNDLTASLMVALDSNNTMPFTPAAMRSETLGFYPWKPTIPTPWRY
YFQWDRTLIPSHTGTSGTPTNVYHGTDPDDVQFYTIENSVPVHLLRTGDEFATGTFFFDCKPCRLTHTWQ
TNRALGLPPFLNSLPQSEGATNFGDIGVQQDKRRGVTQMGNTDYITEATIMRPAEVGYSAPYYSFEASTQ
GPFKTPIAAGRGGAQTDENQAADGDPRYAFGRQHGQKTTTTGETPERFTYIAHQDTGRYPEGDWIQNINF
NLPVTNDNVLLPTDPIGGKTGINYTNIFNTYGPLTALNNVPPVYPNGQIWDKEFDTDLKPRLHVNAPFVC
QNNCPGQLFVKVAPNLTNEYDPDASANMSRIVTYSDFWWKGKLVFKAKLRASHTWNPIQQMSINVDNQFN
YVPNNIGAMKIVYEKSQLAPRKLY

Molecule Role : Protective antigen
Molecule Role Annotation : (Yang et al., 2008)

III. Vaccine Information

1. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 15B5.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001843

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

2. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 15B5.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001844

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

3. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Modified Live & Killed Virus Vaccine (USDA: 15B9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001845

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

4. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia Modified Live & Killed Virus Vaccine (USDA: 15B9.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001846

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

5. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 1559.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001847

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

6. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 1559.23)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001848

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

7. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live & Killed Virus, Killed Chlamydia Vaccine (USDA: 1559.2C)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001849

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

8. Feline Leukemia-Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live & Killed Virus, Modified Live Chlamydia Vaccine (USDA: 1559.2B)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001850

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

9. Feline Panleukopenia Killed Virus Vaccine (USDA: 1565.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001550

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

10. Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.00)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001551

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

11. Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001552

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

12. Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.21)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001553

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

13. Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.23)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001554

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

14. Feline Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 16D5.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001853

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

15. Feline Rhinotracheitis-Calici-Panleukopenia Killed Virus Vaccine (USDA: 16D5.23)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001854

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

16. Feline Rhinotracheitis-Calici-Panleukopenia Modified Live & Killed Virus Vaccine (USDA: 16D9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001855

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

17. Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.20)

a. Manufacturer:

Wyeth, Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001856

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

18. Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.22)

a. Manufacturer:

Wyeth, Intervet Inc., Heska Corporation

b. Vaccine Ontology ID:

VO_0001857

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

19. Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.23)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001858

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

20. Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D1.24)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001859

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

21. Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D8.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001860

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

22. Feline Rhinotracheitis-Calici-Panleukopenia Modified Live Virus Vaccine (USDA: 16D8.21)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001861

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

23. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 16E5.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001862

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

24. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Killed Virus, Killed Chlamydia Vaccine (USDA: 16E5.23)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001863

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

25. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Killed Chlamydia Vaccine (USDA: 16E6.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001864

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

26. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16E1.20)

a. Manufacturer:

Wyeth, Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001865

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

27. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16E1.24)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001866

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

28. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci Modified Live Virus, Modified Live Chlamydia Vaccine (USDA: 16E8.20)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001867

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

29. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci-Rabies Modified Live & Killed Virus, Modified Live Chlamydia Vaccine (USDA: 1619.20)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001868

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

30. Feline Rhinotracheitis-Calici-Panleukopenia-Chlamydia Psittaci-Rabies Modified Live Virus and Chlamydia, Canarypox Vector Vaccine (USDA: 1619.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001869

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

31. Feline Rhinotracheitis-Calici-Panleukopenia-Rabies Modified Live & Killed Virus Vaccine (USDA: 16T9.20)

a. Manufacturer:

Intervet Inc., Merial, Inc.

b. Vaccine Ontology ID:

VO_0001870

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

32. Feline Rhinotracheitis-Calici-Panleukopenia-Rabies Modified Live Virus, Canarypox Vector Vaccine (USDA: 16T9.R0)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001871

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cat

IV. References

1. Truyen et al., 2009: Truyen U, Addie D, Belák S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E, Horzinek MC. Feline panleukopenia. ABCD guidelines on prevention and management. Journal of feline medicine and surgery. 2009; 11(7); 538-546. [PubMed: 19481033].

2. Wiki: Feline Panleukopenia: Wiki: Feline Panleukopenia [http://en.wikipedia.org/wiki/Feline_Panleukopenia]

3. Yang et al., 2008: Yang S, Xia X, Qiao J, Liu Q, Chang S, Xie Z, Ju H, Zou X, Gao Y. Complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing VP2 from FPV. Vaccine. 2008; 26(11); 1482-1487. [PubMed: 18313810].