Gene ID |
Gene Name |
Sequence Strain (Species/Organism) |
VO ID |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
3D structure: PDB ID |
Other Database IDs |
Protein Name |
Molecule Role |
Vaccines Involving this Gene |
118
|
Ag85B from M. tuberculosis H37Rv |
Mycobacterium tuberculosis H37Rv |
VO_0012364
|
885785
|
|
15609023
|
Rv1886c |
AL123456 |
NP_216402 |
|
EMBL: AE000516 EMBL: AF198032 EMBL: BX842578 EMBL: U38939 EMBL: X62398 GenomeReviews: AE000516_GR GenomeReviews: AL123456_GR InterPro: IPR000801 KEGG: mtc:MT1934 KEGG: mtu:Rv1886c PDB: 1F0N PDB: 1F0P Pfam: PF00756 PIR: C70516 TIGR: MT1934 TubercuList: Rv1886c UniProt: P31952 |
diacylglycerol acyltransferase/mycolyltransferase Ag85B |
Protective antigen |
Arabinomannan-tetanus toxoid conjugate
Ag85B and ESAT-6 fusion protein
M. tuberculosis DNA Vaccine encoding Ag85B Protein
MVA/IL-15/5Mtb vaccine
M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83
rBCG-Ag85A/ Ag85B
LT-BCG- Ag85B /Rv3425
|
588
|
Apa |
Mycobacterium tuberculosis H37Rv |
VO_0011175
|
885896
|
|
57116926
|
Rv1860 |
AL123456 |
YP_177849 |
|
|
hypothetical protein |
Protective antigen |
M. tuberculosis DNA Vaccine APADNA priming and APAMVA boosting
|
1829
|
bfrA |
Mycobacterium tuberculosis H37Rv |
|
885767
|
|
15609013
|
Rv1876 |
AL123456 |
NP_216392 |
|
|
bacterioferritin BfrA |
Protective antigen |
BCG-DHTM
|
866
|
DnaK |
Mycobacterium tuberculosis H37Rv |
VO_0012408
|
885946
|
|
15607491
|
Rv0350 |
AL123456 |
NP_214864 |
|
|
chaperone protein DnaK |
Protective antigen |
BCG-DHTM
|
909
|
drrC |
Mycobacterium tuberculosis H37Rv |
|
888491
|
|
15610075
|
Rv2938 |
BX842581 |
NP_217454 |
|
|
daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC |
Virmugen |
Mycobacterium tuberculosis drrC mutant vaccine
|
104
|
EsxA (ESAT-6) |
Mycobacterium tuberculosis H37Rv |
VO_0010919
|
886209
|
|
57117165
|
Rv3875 |
AL123456 |
YP_178023 |
|
EMBL: AE000516 EMBL: AF004671 EMBL: AF420491 EMBL: BX842584 EMBL: X79562 GenomeReviews: AE000516_GR GenomeReviews: AL123456_GR InterPro: IPR010310 KEGG: mtc:MT3989 KEGG: mtu:Rv3875 PDB: 1WA8 Pfam: PF06013 PIR: A70803 TIGR: MT3989 TubercuList: Rv3875 UniProt: P0A564 |
ESAT-6 protein EsxA |
Protective antigen |
recombinant S. typhimurium secreting M. tuberculosis ESAT-6
Ag85B and ESAT-6 fusion protein
MVA/IL-15/5Mtb vaccine
|
121
|
EsxB |
Mycobacterium tuberculosis H37Rv |
VO_0010951
|
886194
|
|
15611010
|
Rv3874 |
AF004671 |
NP_218391 |
3FAV
|
EMBL: AE000516 EMBL: AF004671 EMBL: AF419854 EMBL: BX842584 GenomeReviews: AE000516_GR GenomeReviews: AL123456_GR InterPro: IPR010310 KEGG: mtc:MT3988 KEGG: mtu:Rv3874 Pfam: PF06013 PIR: H70802 SMR: P0A566 TIGR: MT3988 TubercuList: Rv3874 UniProt: P0A566 |
ESAT-6-like protein EsxB |
Protective antigen |
|
4396
|
esxV |
Mycobacterium tuberculosis H37Rv |
|
|
|
NP_218136
|
|
|
|
|
CDD:310537 |
ESAT-6 like protein EsxV |
Protective antigen |
ID93/GLA-SE
|
4397
|
esxW |
Mycobacterium tuberculosis H37Rv |
|
|
|
NP_218137
|
|
|
|
|
CDD:310537 |
ESAT-6 like protein EsxW |
Protective antigen |
ID93/GLA-SE
|
906
|
fadD26 |
Mycobacterium tuberculosis H37Rv |
|
887603
|
|
57117038
|
Rv2930 |
BX842581 |
NP_217446 |
|
|
acyl-CoA synthetase |
Virmugen |
Mycobacterium tuberculosis fadD26 mutant vaccine
|
122
|
FbpA (Ag85A) |
Mycobacterium tuberculosis H37Rv |
VO_0010952
|
886132
|
|
15610940
|
Rv3804c |
AL123456 |
NP_218321 |
1SFR
|
EMBL: AE000516 EMBL: BX842584 EMBL: M27016 EMBL: U47335 GenomeReviews: AE000516_GR GenomeReviews: AL123456_GR InterPro: IPR000801 KEGG: mtc:MT3911 KEGG: mtu:Rv3804c PDB: 1SFR Pfam: PF00756 PIR: H70887 TIGR: MT3911 TubercuList: Rv3804c UniProt: P0A4V2 |
diacylglycerol acyltransferase/mycolyltransferase Ag85A |
Protective antigen |
MVA85A prime and BCG boost
rBCG-Ag85A[Tokyo]
DNA vaccine co-expressing A85A and caspase-3
MVA/IL-15/5Mtb vaccine
M. tuberculosis DNA vaccine pcDNA3.1+/Ag85A DNA encoding Ag85A
M. tuberculosis DNA vaccine DNAAg85A encoding a single immunogenic M.tb Ag
rBCG-Ag85A/ Ag85B
|
814
|
FbpD |
Mycobacterium bovis BCG str. Tokyo 172 |
VO_0012366
|
7562680
|
|
224992215
|
JTY_3867 |
AP010918 |
YP_002646905 |
1R88
|
|
MPT51/MPB51 antigen protein |
Protective antigen |
|
821
|
HBHA |
Mycobacterium tuberculosis H37Ra |
VO_0012373
|
5211814
|
|
148660242
|
MRA_0482 |
CP000611 |
YP_001281765 |
|
|
iron-regulated heparin binding hemagglutinin Hbha |
Protective antigen |
M. tuberculosis HBHA Protein Vaccine
|
817
|
KatG |
Mycobacterium tuberculosis H37Rv |
VO_0012369
|
885638
|
|
15609045
|
Rv1908c |
AL123456 |
NP_216424 |
1SJ2
|
|
catalase-peroxidase |
Protective antigen |
M. tuberculosis DNA Vaccine encoding KatG
M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs)
|
951
|
leuD |
Mycobacterium tuberculosis H37Rv |
|
888225
|
|
15610124
|
Rv2987c |
BX842581 |
NP_217503 |
3H5J
|
|
isopropylmalate isomerase small subunit |
Virmugen |
Mycobacterium tuberculosis leuD mutant vaccine
|
952
|
lysA |
Mycobacterium tuberculosis H37Rv |
|
886960
|
|
15608433
|
Rv1293 |
BX842576 |
NP_215809 |
1HKW
|
|
diaminopimelate decarboxylase LysA |
Virmugen |
Mycobacterium tuberculosis lysA/secA2 mutant vaccine
|
991
|
mce-2 |
Mycobacterium tuberculosis CDC1551 |
|
925014
|
|
15839991
|
MT0618 |
AE000516 |
NP_335028 |
|
|
virulence factor |
Virmugen |
Mycobacterium tuberculosis mce-2 mutant vaccine
|
992
|
mce-3 |
Mycobacterium tuberculosis CDC1551 |
|
923491
|
|
15841441
|
MT2018 |
AE000516 |
NP_336478 |
|
|
virulence factor |
Virmugen |
Mycobacterium tuberculosis mce-2 mutant vaccine
Mycobacterium tuberculosis mce-3 mutant vaccine
|
589
|
Mpt63 |
Mycobacterium tuberculosis H37Rv |
VO_0011176
|
885334
|
|
15609063
|
Rv1926c |
AL123456 |
NP_216442 |
1LMI
|
|
immunogenic protein Mpt63 |
Protective antigen |
|
815
|
MPT64 |
Mycobacterium tuberculosis H37Rv |
VO_0012367
|
885925
|
|
15609117
|
Rv1980c |
A42312 |
NP_216496 |
2HHI
|
|
immunogenic protein Mpt64 |
Protective antigen |
M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83
M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs)
|
867
|
MPT83 |
Mycobacterium tuberculosis H37Rv |
VO_0012409
|
887155
|
|
15610010
|
Rv2873 |
AL123456 |
NP_217389 |
|
|
cell surface lipoprotein |
Protective antigen |
M. tuberculosis DNA vaccine encoding Ag85B, MPT64 and MPT83
M. tuberculosis DNA vaccine (containing the ESAT-6, MPT-64, MPT-83, and KatG constructs)
|
584
|
Mtb72F |
Mycobacterium tuberculosis |
VO_0011173
|
|
|
283801990
|
|
|
|
|
|
|
Protective antigen |
M. tuberculosis Mtb72F Protein Subunit Vaccine
|
910
|
panC |
Mycobacterium tuberculosis H37Rv |
|
885459
|
|
15610738
|
Rv3602c |
BX842583 |
NP_218119 |
|
|
pantoate--beta-alanine ligase |
Virmugen |
Mycobacterium tuberculosis panCD mutant vaccine
Mycobacterium tuberculosis RD1/panCD mutant vaccine
|
911
|
panD |
Mycobacterium tuberculosis H37Rv |
|
885596
|
|
15610737
|
Rv3601c |
BX842583 |
NP_218118 |
|
|
aspartate alpha-decarboxylase |
Virmugen |
Mycobacterium tuberculosis panCD mutant vaccine
Mycobacterium tuberculosis RD1/panCD mutant vaccine
|
819
|
PE20 |
Mycobacterium tuberculosis H37Rv |
VO_0012371
|
885537
|
|
57116919
|
Rv1806 |
JLDD01000021 |
YP_177843 |
|
|
PE family protein PE20 |
Protective antigen |
DNA vaccine Rv1806-1807
|
123
|
PepA |
Mycobacterium tuberculosis H37Rv |
VO_0010953
|
886924
|
|
15607267
|
Rv0125 |
CP003248 |
NP_214639 |
|
|
serine protease PepA |
Protective antigen |
Mtb72f fusion protein
|
249
|
PhoP |
Mycobacterium tuberculosis H37Rv |
|
888772
|
|
15607897
|
Rv0757 |
BX842574 |
NP_215271 |
3R0J
|
|
two component system response transcriptional positive regulator PHOP |
Virmugen |
M. tuberculosis phoP mutant SO2
|
822
|
PPE14 |
Mycobacterium tuberculosis H37Rv |
VO_0012374
|
885069
|
|
57116795
|
Rv0915c |
AL123456 |
YP_177765 |
|
|
PPE family protein PPE14 |
Protective antigen |
|
124
|
PPE18 |
Mycobacterium tuberculosis H37Rv |
VO_0010954
|
886073
|
|
57116841
|
Rv1196 |
AL123456 |
YP_177795 |
|
|
PPE family protein PPE18 |
Protective antigen |
Mtb72f fusion protein
|
820
|
PPE31 |
Mycobacterium tuberculosis H37Rv |
VO_0012372
|
885072
|
|
WP_003409179
|
Rv1807 |
AL123456 |
YP_177653 |
|
CDD:227938 |
PPE family protein |
Protective antigen |
DNA vaccine Rv1806-1807
|
4398
|
PPE42 |
Mycobacterium tuberculosis H37Rv |
|
|
|
YP_177893
|
|
|
|
|
CDD:307116 CDD:279771 CDD:311933 |
PPE family protein PPE42 |
Protective antigen |
ID93/GLA-SE
|
907
|
proC |
Mycobacterium tuberculosis H37Rv |
|
887256
|
|
15607641
|
Rv0500 |
BX842573 |
NP_215014 |
|
|
pyrroline-5-carboxylate reductase |
Virmugen |
Mycobacterium tuberculosis proC mutant vaccine
|
865
|
PstS1 |
Mycobacterium tuberculosis H37Rv |
VO_0012407
|
885724
|
|
57116801
|
Rv0934 |
AL123456 |
YP_177770 |
1PC3
|
|
phosphate ABC transporter substrate-binding lipoprotein PstS |
Protective antigen |
|
818
|
PstS3 |
Mycobacterium tuberculosis H37Rv |
VO_0012370
|
885366
|
|
57116798
|
Rv0928 |
AL123456 |
YP_177768 |
|
|
phosphate ABC transporter substrate-binding lipoprotein PstS |
Protective antigen |
|
1015
|
RD1 |
Mycobacterium tuberculosis H37Rv |
|
885777
|
|
15610750
|
Rv3614c |
BX842583 |
NP_218131 |
|
|
hypothetical protein |
Virmugen |
Mycobacterium tuberculosis RD1/panCD mutant vaccine
|
4395
|
Rv1813c |
Mycobacterium tuberculosis H37Rv |
|
|
|
NP_216329
|
|
|
|
|
CDD:316353 |
hypothetical protein |
Protective antigen |
ID93/GLA-SE
|
1064
|
Rv2660c |
Mycobacterium tuberculosis H37Rv |
|
887222
|
|
15609797
|
Rv2660c |
CP009480 |
NP_217176 |
|
|
hypothetical protein |
Protective antigen |
|
117
|
SecA2 |
Mycobacterium tuberculosis H37Rv |
VO_0010950
|
885594
|
|
15608958
|
Rv1821 |
BX842577 |
NP_216337 |
1NL3
|
EMBL: AE000516 EMBL: BX842577 GenomeReviews: AE000516_GR GenomeReviews: AL123456_GR HSSP: O05885 InterPro: IPR000185 InterPro: IPR001650 InterPro: IPR011115 InterPro: IPR011116 InterPro: IPR011130 InterPro: IPR014018 InterPro: IPR014021 KEGG: mtc:MT1869 KEGG: mtu:Rv1821 Pfam: PF01043 Pfam: PF07516 Pfam: PF07517 PIR: F70720 PRINTS: PR00906 PROSITE: PS01312 PROSITE: PS51196 TIGR: MT1869 TubercuList: Rv1821 UniProt: P66785 |
preprotein translocase subunit SecA |
Virmugen |
M. tuberculosis secA2 mutant
Mycobacterium tuberculosis lysA/secA2 mutant vaccine
|
905
|
sigE |
Mycobacterium tuberculosis H37Rv |
|
888751
|
|
15608361
|
Rv1221 |
BX842575 |
NP_215737 |
|
|
RNA polymerase sigma factor SigE |
Virmugen |
Mycobacterium tuberculosis sigE mutant vaccine
|
1196
|
sigF |
Mycobacterium tuberculosis CDC1551 |
|
922492
|
|
15842877
|
MT3385 |
AE000516 |
NP_337914 |
|
|
RNA polymerase sigma factor SigF |
Virmugen |
Mycobacterium tuberculosis DeltasigF mutant vaccine
|
120
|
SodA |
Mycobacterium tuberculosis H37Rv |
|
886174
|
|
15610982
|
Rv3846 |
NC_000962.2 |
NC_000962.2 |
|
EMBL: AE000516
EMBL: AF061030
EMBL: BX842584
EMBL: X52861
Gene3D: G3DSA:3.90.149.10
GenomeReviews: AE000516_GR
GenomeReviews: AL123456_GR
InterPro: IPR001189
KEGG: mtc:MT3960
KEGG: mtu:Rv3846
LinkHub: P17670
PANTHER: PTHR11404
PDB: 1GN2
PDB: 1GN3
PDB: 1GN4
PDB: 1GN6
PDB: 1IDS
Pfam: PF00081
Pfam: PF02777
PIR: S15205
PRINTS: PR01703
ProDom: PD000475
PROSITE: PS00088
TIGR: MT3960
TubercuList: Rv3846
UniProt: P17670
|
SUPEROXIDE DISMUTASE [FE] SODA |
|
M. tuberculosis DNA vaccine pAK4-sod
|
908
|
trpD |
Mycobacterium tuberculosis H37Rv |
|
887681
|
|
15609329
|
Rv2192c |
BX842579 |
NP_216708 |
2BPQ
|
|
anthranilate phosphoribosyltransferase |
Virmugen |
Mycobacterium tuberculosis trpD mutant vaccine
|