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amorphous aluminum hydroxyphosphate sulfate adjuvant |
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Vaxjo ID |
79 |
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Vaccine Adjuvant Name |
amorphous aluminum hydroxyphosphate sulfate adjuvant |
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Alternative Names |
AAHSA, Merck Aluminum Adjuvant |
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Adjuvant VO ID |
VO_0001323
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Description |
Merck Aluminum Adjuvant (AAHS) is a proprietary aluminum hydroxyphosphate sulfate formulation that is both physically and functionally distinct from traditional aluminum phosphate and aluminum hydroxide adjuvants. At a macromolecular level, AAHS is structurally related to aluminum phosphate as it forms an amorphous mesh‑like structure. AAHS bears a nearly zero charge at neutral pH (Caulfield et al., 2007). |
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Stage of Development |
Licensed |
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Location Licensed |
United States |
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Host Species for Licensed Use |
2 |
| Related Vaccine(s) |
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| References |
Caulfield et al., 2007: Caulfield MJ, Shi L, Wang S, Wang B, Tobery TW, Mach H, Ahl PL, Cannon JL, Cook JC, Heinrichs JH, Sitrin RD. Effect of alternative aluminum adjuvants on the absorption and immunogenicity of HPV16 L1 VLPs in mice. Human vaccines. 2007; 3(4); 139-145. [PubMed: 17581283].
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