nanoemulsion vaccine adjuvant |
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Vaxjo ID |
75 |
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Vaccine Adjuvant Name |
nanoemulsion vaccine adjuvant |
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Adjuvant VO ID |
VO_0001319
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|
Description |
Nanoemulsions are non-toxic lipid droplets a few hundred nanometers in diameter and made from surfactants approved for human consumption and common food substances that are 'Generally Recognized as Safe' (GRAS) by the FDA (M-NIMBS Website). |
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Stage of Development |
Clinical Trial |
|
Preparation |
These emulsions are easily produced in large quantities by mixing a water-immiscible oil phase into an aqueous phase with a high-stress, mechanical extrusion process that is available worldwide.
This process yields a uniform population of droplet particles that are stable for years even at elevated temperatures (M-NIMBS Website). |
|
Function |
Studies have indicated that nanoemulsions have broad-spectrum antimicrobial activity against bacteria, enveloped viruses, fungi, protozoa and spores, due to their ability to lyse these organisms. In contrast, studies of nanoemulsions in animals have shown these compounds to be very well tolerated on the skin and mucous membranes (M-NIMBS Website). |
| Related Vaccine(s) |
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| References |
M-NIMBS Website: Nanoemulsions [http://nano.med.umich.edu/platforms/Nanoemulsions.html]
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