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Quil-A vaccine adjuvant
Vaxjo ID	73
Vaccine Adjuvant Name	Quil-A vaccine adjuvant
Adjuvant VO ID	VO_0001263
Stage of Development	Licensed
Host Species for Licensed Use	36
Components	Purified extract from the bark of the South American tree Quillaja saponaria Molina (Vogel and Powell, 1995).
Function	Quil-A is used in veterinary vaccines and for production of ISCOMs. It induces both humoral and cell-mediated responses (Vogel and Powell, 1995).
Safety	Quil-A is highly irritating to mucosa, so inhalation and eye contact with Quil-A is to be avoided. Quil-A contains hemolysing saponins. Quil-A is not used in human trials because of overt toxicity. It is, however, used extensively in veterinary vaccines (Vogel and Powell, 1995).
Related Vaccine(s)	Subunit vaccine Cancer Vaccine using E7 protein of human papillomavirus 16 and Quil-A (Cancer) N. meningitidis NspA Protein Vaccine (Neisseria meningitidis) S. agalactiae Sip Protein Vaccine (Streptococcus agalactiae) Shiga Toxin 2 B Subunit Vaccine (Escherichia coli) DNA vaccine T. cruzi vaccine encoding TcG2 and TcG4 (Trypanosoma cruzi) Inactivated or "killed" vaccine Leishmune (Leishmania donovani)
References	Vogel and Powell, 1995: Vogel FR, Powell MF. A compendium of vaccine adjuvants and excipients. Pharmaceutical biotechnology. 1995; 6; 141-228. [PubMed: 7551218].