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AS04 |
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Vaxjo ID |
25 |
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Vaccine Adjuvant Name |
AS04 |
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Adjuvant VO ID |
VO_0001265
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Description |
AS04 is a combination of alum and the Lipopolysaccharide (LPS) derivative Monophosphoryl Lipid A (MPL) (McKee et al., 2007). |
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Stage of Development |
Licensed |
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Location Licensed |
USA |
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Host Species for Licensed Use |
2 |
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Components |
AS04 combines 50 μg of the immunoenhancer MPL (3-O-desacyl-4′-monophosphoryl lipid A) with 500 μg of aluminium salt (Garçon et al., 2011). |
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Function |
The rapid and transient stimulation instigated by AS04 allows antigen-presenting cells to process and present antigens at a time when the vaccine antigen concentration is high (Garçon et al., 2011). |
| Related Vaccine(s) |
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| References |
Garçon et al., 2011: Garçon N, Segal L, Tavares F, Van Mechelen M. The safety evaluation of adjuvants during vaccine development: The AS04 experience. Vaccine. 2011; ; . [PubMed: 21527299].
McKee et al., 2007: McKee AS, Munks MW, Marrack P. How do adjuvants work? Important considerations for new generation adjuvants. Immunity. 2007; 27(5); 687-690. [PubMed: 18031690].
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