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Alhydroxiquim-II

Vaxjo ID 113
Vaccine Adjuvant Name Alhydroxiquim-II
Alternative Names Algel-IMDQ
Adjuvant VO ID VO_0005301
Description small molecule with TLR7/TLR8 receptor; activates an agonistic TLR7/TLR8 response in lymph nodes when small molecule detaches from alum; causes Th1 immune system response
Location Licensed COVAXIN licensed in India uses this adjuvant
Host Species for Licensed Use Human
Safety It is a stable adjuvant. It appears overall safe since it has been used in the licensed COVAXIN vaccine against COVID-19.
Related Vaccine(s)
References
Ella et al., 2021: Ella R, Vadrevu KM, Jogdand H, Prasad S, Reddy S, Sarangi V, Ganneru B, Sapkal G, Yadav P, Abraham P, Panda S, Gupta N, Reddy P, Verma S, Kumar Rai S, Singh C, Redkar SV, Gillurkar CS, Kushwaha JS, Mohapatra S, Rao V, Guleria R, Ella K, Bhargava B. Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: a double-blind, randomised, phase 1 trial. The Lancet. Infectious diseases. 2021; 21(5); 637-646. [PubMed: 33485468].
VAC #12: [https://vac.niaid.nih.gov/view?id=12]